ArticleGenetics2000
A reexamination of spreading of position-effect variegation in the white-roughest region of Drosophila melanogaster.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed.
- Species-specific chromatin landscape determines how transposable elements shape genome evolution.eLife · 2022Article
- Live analysis of position-effect variegation inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Role of H3K9me3 heterochromatin in cell identity establishment and maintenance.Current opinion in genetics & development · 2019Review
- A massively parallel reporter assay dissects the influence of chromatin structure on cis-regulatory activity.Nature biotechnology · 2018Article
- Ten principles of heterochromatin formation and function.Nature reviews. Molecular cell biology · 2018Review
- Generalized nucleation and looping model for epigenetic memory of histone modifications.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- New Insights into the Regulation of Heterochromatin.Trends in genetics : TIG · 2016Review
- Position-effect variegation, heterochromatin formation, and gene silencing in Drosophila.Cold Spring Harbor perspectives in biology · 2013Review
- Juxtaposition of heterochromatic and euchromatic regions by chromosomal translocation mediates a heterochromatic long-range position effect associated with a severe neurological phenotype.Molecular cytogenetics · 2012Article
- Ribosomal DNA deletions modulate genome-wide gene expression: "rDNA-sensitive" genes and natural variation.PLoS genetics · 2011Article
- The Drosophila homolog of the mammalian imprint regulator, CTCF, maintains the maternal genomic imprint in Drosophila melanogaster.BMC biology · 2010Article
- The evolution of epitype.The Plant cell · 2010Article
- Domains of heterochromatin protein 1 required for Drosophila melanogaster heterochromatin spreading.Genetics · 2009Article
- The multi-AT-hook chromosomal protein of Drosophila melanogaster, D1, is dispensable for viability.Genetics · 2009Article
- A lot about a little dot - lessons learned from Drosophila melanogaster chromosome 4.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2009Review
- High-resolution mapping of heterochromatin redistribution in a Drosophila position-effect variegation model.Epigenetics & chromatin · 2009Article
- An investigation of heterochromatin domains on the fourth chromosome of Drosophila melanogaster.Genetics · 2008Article
- Review
- Cell-by-cell dissection of gene expression and chromosomal interactions reveals consequences of nuclear reorganization.PLoS biology · 2005Article
- Sequence elements in cis influence heterochromatic silencing in trans.Molecular and cellular biology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Drosophila, heterochromatin causes mosaic silencing of euchromatic genes brought next to it by chromosomal rearrangements. Silencing has been observed to "spread": genes closer to the heterochromatic rearrangement breakpoint are silenced more frequently than genes farther away. We have examined silencing of the white and roughest genes in the variegating rearrangements In(1)w(m4), In(1)w(mMc), and In(1)w(m51b). Eleven stocks bearing these chromosomes differ widely in the strength of silencing of white and roughest. Stock-specific differences in the relative frequencies of inactivation of white and roughest were found that map to the white-roughest region or the adjacent heterochromatin. Most stock-specific differences did not correlate with gross differences in the heterochromatic content of the rearranged chromosomes; however, two stocks, In(1)w(m51b) and In(1)w(mMc), were found to have anomalous additional heterochromatin that may act in trans to suppress variegating alleles. In comparing different stocks, the frequency of silencing of the roughest gene, which is more distant from heterochromatin, does not correlate with the frequency of silencing of the more proximal white gene on the same chromosome, in contradiction to the expectation of models of continuous linear propagation of silencing. We frequently observed rough eye tissue that is pigmented, as though an active white gene is skipped.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.