ArticleGenetics2000
Analysis of the mechanism by which glucose inhibits maltose induction of MAL gene expression in Saccharomyces.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 50 citations in OpenAlex.
- Maltose and Maltotriose Transporters in Brewer'sInternational journal of molecular sciences · 2025Review
- Protein Biosynthesis and Carbon Catabolite Repression Are Transcriptionally Upregulated in Saccharomyces cerevisiae by Extracellular Fractions From Several Wine Yeast Species.Microbial biotechnology · 2025Article
- Packing a punch: understanding how flavours are produced in lager fermentations.FEMS yeast research · 2021Review
- Endocytosis of nutrient transporters in fungi: The ART of connecting signaling and trafficking.Computational and structural biotechnology journal · 2021Review
- Determinants of selection in yeast evolved by genome shuffling.Biotechnology for biofuels · 2018Article
- Population diversification in a yeast metabolic program promotes anticipation of environmental shifts.PLoS biology · 2015Article
- Regulations of sugar transporters: insights from yeast.Current genetics · 2013Review
- Enhanced leavening properties of baker's yeast overexpressing MAL62 with deletion of MIG1 in lean dough.Journal of industrial microbiology & biotechnology · 2012Article
- Characterization of a new multigene family encoding isomaltases in the yeast Saccharomyces cerevisiae, the IMA family.The Journal of biological chemistry · 2010Article
- Aspergillus fumigatus catalytic glucokinase and hexokinase: expression analysis and importance for germination, growth, and conidiation.Eukaryotic cell · 2010Article
- Reconstruction and logical modeling of glucose repression signaling pathways in Saccharomyces cerevisiae.BMC systems biology · 2009Article
- Metabolomic signatures of inbreeding at benign and stressful temperatures in Drosophila melanogaster.Genetics · 2008Article
- Fermentation of high concentrations of maltose by Saccharomyces cerevisiae is limited by the COMPASS methylation complex.Applied and environmental microbiology · 2006Article
- Sequences in the N-terminal cytoplasmic domain of Saccharomyces cerevisiae maltose permease are required for vacuolar degradation but not glucose-induced internalization.Current genetics · 2006Article
- Article
- Glucose signaling in Saccharomyces cerevisiae.Microbiology and molecular biology reviews : MMBR · 2006Review
- Histone H3 Ser10 phosphorylation-independent function of Snf1 and Reg1 proteins rescues a gcn5- mutant in HIS3 expression.Molecular and cellular biology · 2005Article
- Role of Snf1p in regulation of intracellular sorting of the lactose and galactose transporter Lac12p in Kluyveromyces lactis.Eukaryotic cell · 2005Article
- Mutations in SIN4 and RGR1 cause constitutive expression of MAL structural genes in Saccharomyces cerevisiae.Genetics · 2004Article
- Metabolic signals trigger glucose-induced inactivation of maltose permease in Saccharomyces.Journal of bacteriology · 2000Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Expression of the MAL genes required for maltose fermentation in Saccharomyces cerevisiae is induced by maltose and repressed by glucose. Maltose-inducible regulation requires maltose permease and the MAL-activator protein, a DNA-binding transcription factor encoded by MAL63 and its homologues at the other MAL loci. Previously, we showed that the Mig1 repressor mediates glucose repression of MAL gene expression. Glucose also blocks MAL-activator-mediated maltose induction through a Mig1p-independent mechanism that we refer to as glucose inhibition. Here we report the characterization of this process. Our results indicate that glucose inhibition is also Mig2p independent. Moreover, we show that neither overexpression of the MAL-activator nor elimination of inducer exclusion is sufficient to relieve glucose inhibition, suggesting that glucose acts to inhibit induction by affecting maltose sensing and/or signaling. The glucose inhibition pathway requires HXK2, REG1, and GSF1 and appears to overlap upstream with the glucose repression pathway. The likely target of glucose inhibition is Snf1 protein kinase. Evidence is presented indicating that, in addition to its role in the inactivation of Mig1p, Snf1p is required post-transcriptionally for the synthesis of maltose permease whose function is essential for maltose induction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.