ArticleGenetics2000
Genetic analysis of transcription-associated mutation in Saccharomyces cerevisiae.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Characterization of long G4-rich enhancer-associated genomic regions engaging in a novel loop:loop 'G4 Kissing' interaction.Nucleic acids research · 2020Article
- DNA mismatch repair is required for the host innate response and controls cellular fate after influenza virus infection.Nature microbiology · 2019Article
- Ribonucleotides and Transcription-Associated Mutagenesis in Yeast.Journal of molecular biology · 2017Review
- Genetic instability in budding and fission yeast-sources and mechanisms.FEMS microbiology reviews · 2015Review
- Transcription-associated mutagenesis.Annual review of genetics · 2014Review
- Article
- High levels of transcription stimulate transversions at GC base pairs in yeast.Environmental and molecular mutagenesis · 2013Article
- Transcription as a source of genome instability.Nature reviews. Genetics · 2012Review
- Role for topoisomerase 1 in transcription-associated mutagenesis in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Abasic sites in the transcribed strand of yeast DNA are removed by transcription-coupled nucleotide excision repair.Molecular and cellular biology · 2010Article
- Transcription increases methylmethane sulfonate-induced mutations in alkB strains of Escherichia coli.DNA repair · 2008Article
- Article
- Activation-induced cytidine deaminase action is strongly stimulated by mutations of the THO complex.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Protein coevolution and isoexpression in yeast macromolecular complexes.Comparative and functional genomics · 2007Article
- The exceptionally high rate of spontaneous mutations in the polymerase delta proofreading exonuclease-deficient Saccharomyces cerevisiae strain starved for adenine.BMC genetics · 2004Article
- Identification of a distinctive mutation spectrum associated with high levels of transcription in yeast.Molecular and cellular biology · 2004Article
- Article
- Transcription increases multiple spontaneous point mutations in Salmonella enterica.Nucleic acids research · 2003Article
- Translational selection and yeast proteome evolution.Genetics · 2003Article
- Genetic requirements for spontaneous and transcription-stimulated mitotic recombination in Saccharomyces cerevisiae.Genetics · 2002Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
High levels of transcription are associated with elevated mutation rates in yeast, a phenomenon referred to as transcription-associated mutation (TAM). The transcription-associated increase in mutation rates was previously shown to be partially dependent on the Rev3p translesion bypass pathway, thus implicating DNA damage in TAM. In this study, we use reversion of a pGAL-driven lys2DeltaBgl allele to further examine the genetic requirements of TAM. We find that TAM is increased by disruption of the nucleotide excision repair or recombination pathways. In contrast, elimination of base excision repair components has only modest effects on TAM. In addition to the genetic studies, the lys2DeltaBgl reversion spectra of repair-proficient low and high transcription strains were obtained. In the low transcription spectrum, most of the frameshift events correspond to deletions of AT base pairs whereas in the high transcription strain, deletions of GC base pairs predominate. These results are discussed in terms of transcription and its role in DNA damage and repair.
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Registered trials
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