ArticleGenetics2000
Some features of the mutability of bacteria during nonlethal selection.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- L-Alanine Prototrophic Suppressors Emerge from L-Alanine Auxotroph through Stress-Induced Mutagenesis inMicroorganisms · 2021Article
- Selection and Plasmid Transfer Underlie Adaptive Mutation inGenetics · 2018Article
- Impact of a stress-inducible switch to mutagenic repair of DNA breaks on mutation in Escherichia coli.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Global chromosomal structural instability in a subpopulation of starving Escherichia coli cells.PLoS genetics · 2011Article
- Article
- What limits the efficiency of double-strand break-dependent stress-induced mutation in Escherichia coli?Journal of molecular microbiology and biotechnology · 2011Article
- The transcription elongation factor NusA is required for stress-induced mutagenesis in Escherichia coli.Current biology : CB · 2010Article
- DinB upregulation is the sole role of the SOS response in stress-induced mutagenesis in Escherichia coli.Genetics · 2009Article
- Mutability and importance of a hypermutable cell subpopulation that produces stress-induced mutants in Escherichia coli.PLoS genetics · 2008Article
- UmuD and RecA directly modulate the mutagenic potential of the Y family DNA polymerase DinB.Molecular cell · 2007Article
- Article
- Stress responses and genetic variation in bacteria.Mutation research · 2005Review
- Adaptive amplification and point mutation are independent mechanisms: evidence for various stress-inducible mutation mechanisms.PLoS biology · 2004Article
- Adaptive point mutation and adaptive amplification pathways in the Escherichia coli Lac system: stress responses producing genetic change.Journal of bacteriology · 2004Article
- Adaptive mutation in Escherichia coli.Journal of bacteriology · 2004Article
- General stress response regulator RpoS in adaptive mutation and amplification in Escherichia coli.Genetics · 2004Article
- Article
- Adaptive mutation: general mutagenesis is not a programmed response to stress but results from rare coamplification of dinB with lac.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Error-prone polymerase, DNA polymerase IV, is responsible for transient hypermutation during adaptive mutation in Escherichia coli.Journal of bacteriology · 2003Article
- Article
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Authors and funding
3 authors.
Funding
Abstract
We describe the mutability of the Trp(-) chromosomal +1 frameshift mutation trpE7999 during nonlethal selection, finding that the appearance of Trp(+) revertants behaves similarly to that of episomal Lac(+) revertants. In addition, we show that a feature of the Lac(+) and Trp(+) mutability is the accumulation of Trp(+) and Lac(+) revertants with additional unselected mutations, most of which are not due to heritable mutators. The cells undergoing nonlethal selection apparently experience an epigenetic change resulting in a subset of bacteria with elevated mutability that often remain hypermutable for the duration of selection. The epigenetic change provoked by nonlethal selection appears to be mediated by a unique function provided by the F'128 episome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.