ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Recovery from open channel block by acetylcholine during neuromuscular transmission in zebrafish.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
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- Neuromuscular Block and Blocking Agents in 2018.Turkish journal of anaesthesiology and reanimation · 2018Article
- Observational
- Muscle-Type Nicotinic Receptor Modulation by 2,6-Dimethylaniline, a Molecule Resembling the Hydrophobic Moiety of Lidocaine.Frontiers in molecular neuroscience · 2016Article
- Muscarinic inhibition of nicotinic transmission in rat sympathetic neurons and adrenal chromaffin cells.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Mechanism of activation of the prokaryotic channel ELIC by propylamine: a single-channel study.The Journal of general physiology · 2015Article
- Hydrogen peroxide increases GABAA receptor-mediated tonic current in hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Agonist and blocking actions of choline and tetramethylammonium on human muscle acetylcholine receptors.The Journal of physiology · 2009Article
- Neostigmine but not sugammadex impairs upper airway dilator muscle activity and breathing.British journal of anaesthesia · 2008Article
- Unwarranted administration of acetylcholinesterase inhibitors can impair genioglossus and diaphragm muscle function.Anesthesiology · 2007Article
- Block of muscle nicotinic receptors by choline suggests that the activation and desensitization gates act as distinct molecular entities.The Journal of general physiology · 2006Article
- Paired motor neuron-muscle recordings in zebrafish test the receptor blockade model for shaping synaptic current.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Mechanisms of H+ modulation of glycinergic response in rat sacral dorsal commissural neurons.The Journal of physiology · 2003Article
- Co-expression of the 5-HT3B serotonin receptor subunit alters the biophysics of the 5-HT3 receptor.Biophysical journal · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
At larval zebrafish neuromuscular junctions (NMJs), miniature end plate currents (mEPCs) recorded in vivo have an unusually fast time course. We used fast-flow application of acetylcholine (ACh) onto outside-out patches to mimic the effect of synaptic release onto small numbers of ACh receptor channels (AChRs). Positively charged ACh acted at hyperpolarized potentials and at millimolar concentrations as a fast ("flickering") open channel blocker of AChRs. Because of filtering, the open channel block resulted in reduced amplitude of single channel currents. Immediately after brief (1 msec) application (without significant desensitization) of millimolar ACh at hyperpolarized potentials, a slower, transient current appeared because of delayed reversal of the block. This rebound current depended on the ACh concentration and resembled in time course the mEPC. A simple kinetic model of the AChR that includes an open channel-blocking step accounted for our single channel results, as well as the experimentally observed slowing of the time course of mEPCs recorded at a hyperpolarized compared with a depolarized potential. Recovery from AChR block is a novel mechanism of synaptic transmission that may contribute in part at all NMJs.
Indexed as
Identifiers
10627590PMC6774107W2106543677What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.