SynthesisThe British journal of general practice : the journal of the Royal College of General Practitioners1999
The prognosis of non-critical limb ischaemia: a systematic review of population-based evidence.
Synthesis in The British journal of general practice : the journal of the Royal College of General Practitioners, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 65 citations in OpenAlex.
- Article
- Transplantation of adipose tissue-derived microvascular fragments promotes therapy of critical limb ischemia.Biomaterials research · 2023Article
- Improving Limb Salvage for Chronic Limb-Threatening Ischemia With Spinal Cord Stimulation: A Retrospective Analysis.Vascular and endovascular surgery · 2021Article
- Role of CXCR2 in the Ac-PGP-Induced Mobilization of Circulating Angiogenic Cells and its Therapeutic Implications.Stem cells translational medicine · 2019Article
- Immediate results and long-term cardiovascular outcomes of endovascular therapy in octogenarians and nonoctogenarians with peripheral arterial diseases.Clinical interventions in aging · 2016Article
- Sustained release nitrite therapy results in myocardial protection in a porcine model of metabolic syndrome with peripheral vascular disease.American journal of physiology. Heart and circulatory physiology · 2015Article
- VEGF-loaded graphene oxide as theranostics for multi-modality imaging-monitored targeting therapeutic angiogenesis of ischemic muscle.Nanoscale · 2013Article
- Optimal management of peripheral arterial disease for the non-specialist.The Ulster medical journal · 2011Review
- Plasma nitrite response and arterial reactivity differentiate vascular health and performance.Nitric oxide : biology and chemistry · 2009Article
- Peripheral Arterial Disease study (PERART): prevalence and predictive values of asymptomatic peripheral arterial occlusive disease related to cardiovascular morbidity and mortality.BMC public health · 2007Article
- Localization of a gene for peripheral arterial occlusive disease to chromosome 1p31.American journal of human genetics · 2002Article
- Asymptomatic peripheral artery disease: Silent but deadly.Progress in cardiovascular diseasesReview
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeripheral arterial occlusive disease (PAOD) is the most common peripheral vascular disorder in the elderly. A clear picture of the disease's course, especially in patients with non-critical limb ischaemia (Fontaine stages I and II), is essential for the general practitioner, who plays a key role in the diagnosis and management of PAOD.
aimTo evaluate the population-based evidence on the course and prognosis of PAOD.
methodsAn exhaustive literature search yielded 16 population-based studies on the prognosis of PAOD. The methodological qualities of the studies were assessed according to eight criteria.
resultsThirteen studies of high methodological quality show that data on the course, cardiovascular morbidity, and mortality of asymptomatic PAOD are scarce. Only a small group of asymptomatic patients seem to develop intermittent claudication symptoms. However, asymptomatic patients appear to have the same increased risk for cardiovascular morbidity and mortality when compared with claudicants. No data were available on prognostic factors for intermittent claudication and cardiovascular morbidity in asymptomatic patients. The course, cardiovascular morbidity, and mortality of symptomatic PAOD are better documented. A small group of claudicants experience symptom progression. Smoking, hypertension, increasing age, and diabetes are the most relevant risk factors for intermittent claudication. Claudicants are at a higher risk for developing other cardiovascular diseases, resulting in a significantly increased mortality mainly owing to coronary heart disease. Intermittent claudication and a low ankle-brachial pressure index are significant predictors of mortality. Men had intermittent claudication and symptom progression more often than women. Cardiovascular (co-)morbidity was common in both male and female PAOD patients, but male PAOD patients had a higher mortality compared with female PAOD patients.
conclusionGiven the current knowledge on the prognosis of PAOD in the general population, an important task for (secondary) prevention is reserved for the general practitioner. Further research is required to document the course and prognosis of asymptomatic PAOD patients.
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