ArticleBiophysical journal2000
Acceleration of P/C-type inactivation in voltage-gated K(+) channels by methionine oxidation.
Article in Biophysical journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- Potassium channels as an ionic checkpoint in tumor immunity.Frontiers in pharmacology · 2026Review
- The Oxidized Protein Repair Enzymes Methionine Sulfoxide Reductases and Their Roles in Protecting against Oxidative Stress, in Ageing and in Regulating Protein Function.Antioxidants (Basel, Switzerland) · 2018Review
- In Vivo Effects of Methionine Sulfoxide Reductase Deficiency inAntioxidants (Basel, Switzerland) · 2018Article
- The Effects of 4-Hydroxybenzoic Acid Identified from Bamboo (The Malaysian journal of medical sciences : MJMS · 2018Article
- Preclinical study of a Kv11.1 potassium channel activator as antineoplastic approach for breast cancer.Oncotarget · 2018Article
- Oxidative modulation of voltage-gated potassium channels.Antioxidants & redox signaling · 2014Review
- Shaker IR T449 mutants separate C- from U-type inactivation.The Journal of membrane biology · 2014Article
- S-glutathionylation of an auxiliary subunit confers redox sensitivity to Kv4 channel inactivation.PloS one · 2014Article
- ICA-105574 interacts with a common binding site to elicit opposite effects on inactivation gating of EAG and ERG potassium channels.Molecular pharmacology · 2013Article
- Tuning of EAG K(+) channel inactivation: molecular determinants of amplification by mutations and a small molecule.The Journal of general physiology · 2012Article
- Differential effects of methionine and cysteine oxidation on [Ca2+] i in cultured hippocampal neurons.Cellular and molecular neurobiology · 2009Article
- Slow inactivation in Shaker K channels is delayed by intracellular tetraethylammonium.The Journal of general physiology · 2008Article
- Functional consequences of methionine oxidation of hERG potassium channels.Biochemical pharmacology · 2007Article
- Three methionine residues located within the regulator of conductance for K+ (RCK) domains confer oxidative sensitivity to large-conductance Ca2+-activated K+ channels.The Journal of physiology · 2006Article
- Slow inactivation in voltage gated potassium channels is insensitive to the binding of pore occluding peptide toxins.Biophysical journal · 2005Article
- GABAA receptor kinetics in the cerebellar nuclei: evidence for detection of transmitter from distant release sites.Biophysical journal · 2005Article
- The binding of kappa-Conotoxin PVIIA and fast C-type inactivation of Shaker K+ channels are mutually exclusive.Biophysical journal · 2004Article
- U-type inactivation of Kv3.1 and Shaker potassium channels.Biophysical journal · 2001Article
- A missense mutation in a novel gene encoding a putative cation channel is associated with catatonic schizophrenia in a large pedigree.Molecular psychiatry · 2001Article
- Oxidative regulation of large conductance calcium-activated potassium channels.The Journal of general physiology · 2001Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Oxidation of amino acid residues causes noticeable changes in gating of many ion channels. We found that P/C-type inactivation of Shaker potassium channels expressed in Xenopus oocytes is irreversibly accelerated by patch excision and that this effect was mimicked by application of the oxidant H(2)O(2), which is normally produced in cells by the dismutase action on the superoxide anion. The inactivation time course was also accelerated by high concentration of O(2). Substitution of a methionine residue located in the P-segment of the channel with a leucine largely eliminated the channel's sensitivity to patch excision, H(2)O(2), and high O(2). The results demonstrate that oxidation of methionine is an important regulator of P/C-type inactivation and that it may play a role in mediating the cellular responses to hypoxia/hyperoxia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.