ArticleBiophysical journal2000
Regulation of protein mobility in cell membranes: a dynamic corral model.
Article in Biophysical journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 36 citations in OpenAlex.
- Multi-physics interactions drive VEGFR2 relocation on endothelial cells.Scientific reports · 2017Article
- Membrane Compartmentalization Reducing the Mobility of Lipids and Proteins within a Model Plasma Membrane.The journal of physical chemistry. B · 2016Article
- Molecular force transduction by ion channels: diversity and unifying principles.Journal of cell science · 2012Review
- Characterization of differential protein tethering at the plasma membrane in response to epidermal growth factor signaling.Journal of proteome research · 2012Article
- Neural membrane signaling platforms.International journal of molecular sciences · 2010Review
- Adaptive coarse-grained Monte Carlo simulation of reaction and diffusion dynamics in heterogeneous plasma membranes.BMC bioinformatics · 2010Article
- A dynamic corral model of receptor trafficking at a synapse.Biophysical journal · 2009Article
- Diffusion in a fluid membrane with a flexible cortical cytoskeleton.Biophysical journal · 2009Article
- Implicit solvent simulation models for biomembranes.European biophysics journal : EBJ · 2006Review
- Dynamics of pinned membranes with application to protein diffusion on the surface of red blood cells.Biophysical journal · 2004Article
- Regulation of protein mobility via thermal membrane undulations.Biophysical journal · 2003Article
- Confined diffusion without fences of a g-protein-coupled receptor as revealed by single particle tracking.Biophysical journal · 2003Article
- Lateral diffusion of membrane proteins in the presence of static and dynamic corrals: suggestions for appropriate observables.Biophysical journal · 2000Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We analyze a two-state stochastic corral model for regulation of protein diffusion in a cell membrane. This model could mimic control of protein transport in the membrane by the cytoskeleton. The dynamic corral acts as a gate which when open permits an otherwise trapped protein to escape to a neighboring corral in the cytoskeletal network. We solve for the escape rate over a wide range of parameters of the model, and compare these results with Monte Carlo simulations. Upon introducing measured values of the model parameters for Band 3 in erythrocyte membranes, we are able to estimate the value for one unknown parameter, the average rate at which the corral closes. The ratio of calculated closing rate to measured opening rate is roughly 100:1, consistent with a gating mechanism whereby protein mobility is regulated by dissociation and reassociation of segments of the cytoskeletal network.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.