ArticleBiophysical journal2000
Evidence for cooperativity between nicotinic acetylcholine receptors in patch clamp records.
Article in Biophysical journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 47 citations in OpenAlex.
- Information Entropy Metrics to Address the Complexity of Cooperative Gating of Ion Channels.Entropy (Basel, Switzerland) · 2026Article
- Copper Increases the Cooperative Gating of Rat P2X2a Receptor Channels.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Mechanisms and physiological implications of cooperative gating of clustered ion channels.Physiological reviews · 2022Review
- Direct visualization of ion-channel gating in a native environment.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Intramembrane congestion effects on lysenin channel voltage-induced gating.European biophysics journal : EBJ · 2016Article
- Fast computations in cortical ensembles require rapid initiation of action potentials.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- S6 peptide derived from KvAP channel shows cooperativity in gating on bilayer lipid membrane.PloS one · 2013Article
- Article
- A small fraction of strongly cooperative sodium channels boosts neuronal encoding of high frequencies.PloS one · 2012Article
- The what and where of adding channel noise to the Hodgkin-Huxley equations.PLoS computational biology · 2011Review
- How noisy adaptation of neurons shapes interspike interval histograms and correlations.PLoS computational biology · 2010Article
- Voltage-dependent facilitation of Cx46 hemichannels.American journal of physiology. Cell physiology · 2010Article
- Properties of single two-pore domain TREK-2 channels expressed in mammalian cells.The Journal of physiology · 2007Article
- Cooperative gating between single HCN pacemaker channels.The Journal of general physiology · 2006Article
- Kinetic evidence that desensitized nAChR may promote transitions of active nAChR to desensitized states during sustained exposure to agonists in skeletal muscle.Pflugers Archiv : European journal of physiology · 2006Article
- Evidence for non-independent gating of P2X2 receptors expressed in Xenopus oocytes.BMC neuroscience · 2002Article
- Synchronized activation and refolding of influenza hemagglutinin in multimeric fusion machines.The Journal of cell biology · 2001Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is often assumed that ion channels in cell membrane patches gate independently. However, in the present study nicotinic receptor patch clamp data obtained in cell-attached mode from embryonic chick myotubes suggest that the distribution of steady-state probabilities for conductance multiples arising from concurrent channel openings may not be binomial. In patches where up to four active channels were observed, the probabilities of two or more concurrent openings were greater than expected, suggesting positive cooperativity. For the case of two active channels, we extended the analysis by assuming that 1) individual receptors (not necessarily identical) could be modeled by a five-state (three closed and two open) continuous-time Markov process with equal agonist binding affinity at two recognition sites, and 2) cooperativity between channels could occur through instantaneous changes in specific transition rates in one channel following a change in conductance state of the neighboring channel. This allowed calculation of open and closed sojourn time density functions for either channel conditional on the neighboring channel being open or closed. Simulation studies of two channel systems, with channels being either independent or cooperative, nonidentical or identical, supported the discriminatory power of the optimization algorithm. The experimental results suggested that individual acetylcholine receptors were kinetically identical and that the open state of one channel increased the probability of opening of its neighbor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.