ArticleProceedings of the National Academy of Sciences of the United States of America2000
Identification of bdm-1, a gene involved in G protein beta-subunit function and alpha-subunit accumulation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Applying molecular and genetic methods to trees and their fungal communities.Applied microbiology and biotechnology · 2023Review
- Review
- Article
- Fungal G-Protein-Coupled Receptors: A Promising Mediator of the Impact of Extracellular Signals on Biosynthesis of Ochratoxin A.Frontiers in microbiology · 2021Review
- Genetic and physical interactions between Gα subunits and components of the Gβγ dimer of heterotrimeric G proteins in Neurospora crassa.Eukaryotic cell · 2012Article
- BDM1, a phosducin-like gene of Fusarium graminearum, is involved in virulence during infection of wheat and maize.Molecular plant pathology · 2012Article
- The phosducin-like protein PhLP1 impacts regulation of glycoside hydrolases and light response in Trichoderma reesei.BMC genomics · 2011Article
- Regulators of G-protein signalling in Fusarium verticillioides mediate differential host-pathogen responses on nonviable versus viable maize kernels.Molecular plant pathology · 2011Article
- Phosphorylation of phosducin-like protein BDM-1 by protein kinase 2 (CK2) is required for virulence and G beta subunit stability in the fungal plant pathogen Cryphonectria parasitica.Molecular microbiology · 2010Article
- How a mycoparasite employs g-protein signaling: using the example of trichoderma.Journal of signal transduction · 2010Article
- Differential inhibitor of Gbetagamma signaling to AKT and ERK derived from phosducin-like protein: effect on sphingosine 1-phosphate-induced endothelial cell migration and in vitro angiogenesis.The Journal of biological chemistry · 2009Article
- The information highways of a biotechnological workhorse--signal transduction in Hypocrea jecorina.BMC genomics · 2008Article
- A host factor involved in hypovirus symptom expression in the chestnut blight fungus, Cryphonectria parasitica.Journal of virology · 2008Article
- Function of phosducin-like proteins in G protein signaling and chaperone-assisted protein folding.Cellular signalling · 2007Review
- The phosducin-like protein PhnA is required for Gbetagamma-mediated signaling for vegetative growth, developmental control, and toxin biosynthesis in Aspergillus nidulans.Eukaryotic cell · 2006Article
- The phosducin-like protein PhLP1 is essential for G{beta}{gamma} dimer formation in Dictyostelium discoideum.Molecular and cellular biology · 2005Article
- Phosducin-like protein acts as a molecular chaperone for G protein betagamma dimer assembly.The EMBO journal · 2005Article
- Except in every detail: comparing and contrasting G-protein signaling in Saccharomyces cerevisiae and Schizosaccharomyces pombe.Eukaryotic cell · 2005Review
- The heterotrimeric G-protein subunits GNG-1 and GNB-1 form a Gbetagamma dimer required for normal female fertility, asexual development, and galpha protein levels in Neurospora crassa.Eukaryotic cell · 2005Article
- Article
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3 authors.
Funding
Abstract
Targeted disruption of Galpha and Gbeta genes has established the requirement of an intact G protein signaling pathway for optimal execution of several important physiological processes, including pathogenesis, in the chestnut blight fungus Cryphonectria parasitica. We now report the identification of a G protein signal transduction component, beta disruption mimic factor-1, BDM-1. Disruption of the corresponding gene, bdm-1, resulted in a phenotype indistinguishable from that previously observed after disruption of the Gbeta subunit gene, cpgb-1. The BDM-1 deduced amino acid sequence contained several significant clusters of identity with mammalian phosducin, including a domain corresponding to a highly conserved 11-amino acid stretch that has been implicated in binding to the Gbetagamma dimer and two regions of defined Gbeta/phosducin contact points. Unlike the negative regulatory function proposed for mammalian phosducin, the genetic data presented in this report suggest that BDM-1 is required for or facilitates Gbeta function. Moreover, disruption of either bdm-1 or cpgb-1 resulted in a significant, posttranscriptional reduction in the accumulation of CPG-1, a key Galpha subunit required for a range of vital physiological processes.
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