ArticleProceedings of the National Academy of Sciences of the United States of America2000
Molecular cytogenetic dissection of human chromosomes 3 and 21 evolution.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 86 citations in OpenAlex.
- Cross-species chromosome painting offers new insights into the phylogenetic relationships among 16 representative species of Ipomoeeae.Frontiers in plant science · 2025Article
- Decreased TMEM40 expression is associated with malignant behavior of cutaneous squamous cell carcinoma and inhibits tumor progression.Oncology letters · 2021Article
- Genes with human-specific features are primarily involved with brain, immune and metabolic evolution.BMC bioinformatics · 2019Article
- High expression of TMEM40 is associated with the malignant behavior and tumorigenesis in bladder cancer.Journal of translational medicine · 2018Article
- Directional genomic hybridization: inversions as a potential biodosimeter for retrospective radiation exposure.Radiation and environmental biophysics · 2014Article
- Multiple sex chromosome systems in howler monkeys (Platyrrhini, Alouatta).Comparative cytogenetics · 2014Article
- Gorilla genome structural variation reveals evolutionary parallelisms with chimpanzee.Genome research · 2011Article
- High-resolution chromosome painting reveals the first genetic signature for the chiropteran suborder Pteropodiformes (Mammalia: Chiroptera).Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2011Article
- Hemiplasy and homoplasy in the karyotypic phylogenies of mammals.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Segmental duplications and evolutionary plasticity at tumor chromosome break-prone regions.Genome research · 2008Article
- Primate chromosome evolution: ancestral karyotypes, marker order and neocentromeres.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Review
- Defining the ancestral eutherian karyotype: a cladistic interpretation of chromosome painting and genome sequence assembly data.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Article
- A genetic linkage map of the vervet monkey (Chlorocebus aethiops sabaeus).Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- High-resolution comparative chromosome painting in the Arizona collared peccary (Pecari tajacu, Tayassuidae): a comparison with the karyotype of pig and sheep.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2006Article
- Multi-directional chromosome painting maps homologies between species belonging to three genera of New World monkeys and humans.Chromosoma · 2004Article
- Comparative map between the domestic pig and dog.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
- Recurrent sites for new centromere seeding.Genome research · 2004Article
- A chromosome painting test of the basal eutherian karyotype.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2004Article
- Conservation of aphidicolin-induced fragile sites in Papionini (Primates) species and humans.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2004Article
- Neocentromeres in 15q24-26 map to duplicons which flanked an ancestral centromere in 15q25.Genome research · 2003Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromosome painting in placental mammalians illustrates that genome evolution is marked by chromosomal synteny conservation and that the association of chromosomes 3 and 21 may be the largest widely conserved syntenic block known for mammals. We studied intrachromosomal rearrangements of the syntenic block 3/21 by using probes derived from chromosomal subregions with a resolution of up to 10-15 Mbp. We demonstrate that the rearrangements visualized by chromosome painting, mostly translocations, are only a fraction of the actual chromosomal changes that have occurred during evolution. The ancestral segment order for both primates and carnivores is still found in some species in both orders. From the ancestral primate/carnivore condition an inversion is needed to derive the pig homolog, and a fission of chromosome 21 and a pericentric inversion is needed to derive the Bornean orangutan condition. Two overlapping inversions in the chromosome 3 homolog then would lead to the chromosome form found in humans and African apes. This reconstruction of the origin of human chromosome 3 contrasts with the generally accepted scenario derived from chromosome banding in which it was proposed that only one pericentric inversion was needed. From the ancestral form for Old World primates (now found in the Bornean orangutan) a pericentric inversion and centromere shift leads to the chromosome ancestral for all Old World monkeys. Intrachromosomal rearrangements, as shown here, make up a set of potentially plentiful and informative markers that can be used for phylogenetic reconstruction and a more refined comparative mapping of the genome.
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