ArticleProceedings of the National Academy of Sciences of the United States of America2000
Differential quantal release of histamine and 5-hydroxytryptamine from mast cells of vesicular monoamine transporter 2 knockout mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 84 citations in OpenAlex.
- Potential role of NSAIDs loaded nano-formulations to treat inflammatory diseases.Inflammopharmacology · 2025Review
- How "Neuronal" Are Human Skin Mast Cells?International journal of molecular sciences · 2022Review
- Recent advances in fast-scan cyclic voltammetry.The Analyst · 2020Review
- Mechanism of Histamine Oxidation and Electropolymerization at Carbon Electrodes.Analytical chemistry · 2019Article
- ZnT2 is an electroneutral proton-coupled vesicular antiporter displaying an apparent stoichiometry of two protons per zinc ion.PLoS computational biology · 2019Article
- High-throughput screening system for dynamic monitoring of exocytotic vesicle trafficking in mast cells.PloS one · 2018Article
- Vesicle impact electrochemical cytometry compared to amperometric exocytosis measurements.Current opinion in electrochemistry · 2017Article
- Sexual dimorphism in the mast cell transcriptome and the pathophysiological responses to immunological and psychological stress.Biology of sex differences · 2016Article
- In vivo histamine voltammetry in the mouse premammillary nucleus.The Analyst · 2015Article
- Identification of a mammalian vesicular polyamine transporter.Scientific reports · 2014Article
- Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson disease-related neurodegeneration in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Mast cell mediators: their differential release and the secretory pathways involved.Frontiers in immunology · 2014Review
- Ruthenium red colorimetric and birefringent staining of amyloid-β aggregates in vitro and in Tg2576 mice.ACS chemical neuroscience · 2013Article
- Topical antihistamines display potent anti-inflammatory activity linked in part to enhanced permeability barrier function.The Journal of investigative dermatology · 2013Article
- Electroanalytical eavesdropping on single cell communication.Analytical chemistry · 2011Review
- A glial variant of the vesicular monoamine transporter is required to store histamine in the Drosophila visual system.PLoS genetics · 2008Article
- Mast cells possess distinct secretory granule subsets whose exocytosis is regulated by different SNARE isoforms.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Munc-18-1 regulates the initial release rate of exocytosis.Biophysical journal · 2008Article
- VMAT2 gene expression and function as it applies to imaging beta-cell mass.Journal of molecular medicine (Berlin, Germany) · 2008Review
- Galphao2 regulates vesicular glutamate transporter activity by changing its chloride dependence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The recent availability of mice lacking the neuronal form of the vesicular monoamine transporter 2 (VMAT2) affords the opportunity to study its roles in storage and release. Carbon fiber microelectrodes were used to measure individual secretory events of histamine and 5-hydroxytryptamine (5-HT) from VMAT2-expressing mast cells as a model system for quantal release. VMAT2 is indispensable for monoamine storage because mast cells from homozygous (VMAT2(-/-)) mice, while undergoing granule-cell fusion, do not release monoamines. Cells from heterozygous animals (VMAT2(+/-)) secrete lower amounts of monoamine per granule than cells from wild-type controls. Investigation of corelease of histamine and 5-HT from granules in VMAT2(+/-) cells revealed 5-HT quantal size was reduced more than that of histamine. Thus, although vesicular transport is the limiting factor determining quantal size of 5-HT and histamine release, intragranular association with the heparin matrix also plays a significant role.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.