ArticleProceedings of the National Academy of Sciences of the United States of America2000
IFN consensus sequence binding protein potentiates STAT1-dependent activation of IFNgamma-responsive promoters in macrophages.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 72 citations in OpenAlex.
- The Role of the Placental Enzyme Indoleamine 2,3-Dioxygenase in Normal and Abnormal Human Pregnancy.International journal of molecular sciences · 2024Review
- Inhibition of complement C3 prevents osteoarthritis progression in guinea pigs by blocking STAT1 activation.Communications biology · 2024Article
- Analysis of the human kidney transcriptome and plasma proteome identifies markers of proximal tubule maladaptation to injury.Science translational medicine · 2023Article
- Microglia and Brain Macrophages as Drivers of Glioma Progression.International journal of molecular sciences · 2022Review
- The JAK/STAT signaling pathway: from bench to clinic.Signal transduction and targeted therapy · 2021Review
- Article
- Nc886, a Novel Suppressor of the Type I Interferon Response Upon Pathogen Intrusion.International journal of molecular sciences · 2021Article
- Proteasome Composition in Cytokine-Treated Neurons and Astrocytes is Determined Mainly by Subunit Displacement.Neurochemical research · 2020Article
- Regulatory Networks Involving STATs, IRFs, and NFκB in Inflammation.Frontiers in immunology · 2018Review
- DNA methylation protects against cisplatin-induced kidney injury by regulating specific genes, including interferon regulatory factor 8.Kidney international · 2017Article
- microRNA dysregulation in polyglutamine toxicity of TATA-box binding protein is mediated through STAT1 in mouse neuronal cells.Journal of neuroinflammation · 2017Article
- Article
- Increased expression of interferon signaling genes in the bone marrow microenvironment of myelodysplastic syndromes.PloS one · 2015Article
- Interferon regulatory factor 8/interferon consensus sequence binding protein is a critical transcription factor for the physiological phenotype of microglia.Journal of neuroinflammation · 2012Article
- Molecular mechanisms for synchronized transcription of three complement C1q subunit genes in dendritic cells and macrophages.The Journal of biological chemistry · 2011Article
- LXRα regulates macrophage arginase 1 through PU.1 and interferon regulatory factor 8.Circulation research · 2011Article
- IFN-γ inhibits gastric carcinogenesis by inducing epithelial cell autophagy and T-cell apoptosis.Cancer research · 2011Article
- Cooperative contributions of interferon regulatory factor 1 (IRF1) and IRF8 to interferon-γ-mediated cytotoxic effects on oligodendroglial progenitor cells.Journal of neuroinflammation · 2011Article
- Regulation of interferon and Toll-like receptor signaling during macrophage activation by opposing feedforward and feedback inhibition mechanisms.Immunological reviews · 2008Review
- DNA methylation represses IFN-gamma-induced and signal transducer and activator of transcription 1-mediated IFN regulatory factor 8 activation in colon carcinoma cells.Molecular cancer research : MCR · 2008Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
IFNgamma, once called the macrophage-activating factor, stimulates many genes in macrophages, ultimately leading to the elicitation of innate immunity. IFNgamma's functions depend on the activation of STAT1, which stimulates transcription of IFNgamma-inducible genes through the GAS element. The IFN consensus sequence binding protein (icsbgamma or IFN regulatory factor 8), encoding a transcription factor of the IFN regulatory factor family, is one of such IFNgamma-inducible genes in macrophages. We found that macrophages from ICSBP-/- mice were defective in inducing some IFNgamma-responsive genes, even though they were capable of activating STAT1 in response to IFNgamma. Accordingly, IFNgamma activation of luciferase reporters fused to the GAS element was severely impaired in ICSBP-/- macrophages, but transfection of ICSBP resulted in marked stimulation of these reporters. Consistent with its role in activating IFNgamma-responsive promoters, ICSBP stimulated reporter activity in a GAS-specific manner, even in the absence of IFNgamma treatment, and in STAT1 negative cells. Indicative of a mechanism for this stimulation, DNA affinity binding assays revealed that endogenous ICSBP was recruited to a multiprotein complex that bound to GAS. These results suggest that ICSBP, when induced by IFNgamma through STAT1, in turn generates a second wave of transcription from GAS-containing promoters, thereby contributing to the elicitation of IFNgamma's unique activities in immune cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.