ArticleHeart (British Cardiac Society)2000
Role of endothelial cell denudation and smooth muscle cell dedifferentiation in neointimal formation of human vein grafts after coronary artery bypass grafting: therapeutic implications.
Article in Heart (British Cardiac Society), 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Antithrombotic agents for preventing thrombosis after infrainguinal arterial bypass surgery.The Cochrane database of systematic reviews · 2011Pooled it
- Vein graft preservation solutions, patency, and outcomes after coronary artery bypass graft surgery: follow-up from the PREVENT IV randomized clinical trial.JAMA surgery · 2014Trial
- The consequence of biologic graft processing on blood interface biocompatibility and mechanics.Cardiovascular engineering and technology · 2015Article
- Slow and sustained nitric oxide releasing compounds inhibit multipotent vascular stem cell proliferation and differentiation without causing cell death.Biochemical and biophysical research communications · 2014Article
- Circulating soluble CD40 ligand mediates the interaction between neutrophils and platelets in acute coronary syndrome.Heart and vessels · 2010Article
- Scaffold-free in vitro arterial mimetics: the importance of smooth muscle-endothelium contact.Tissue engineering. Part A · 2010Article
- Adaptive changes in autogenous vein grafts for arterial reconstruction: clinical implications.Journal of vascular surgery · 2010Review
- In vivo human lower extremity saphenous vein bypass grafts manifest flow mediated vasodilation.Journal of vascular surgery · 2009Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo provide better insights into the genesis of neointimal thickening in human vein grafts early after surgery.
designRetrospective study.
settingTertiary referral centre. SUBJECTS: 18 distal anastomotic sites of patent grafts, obtained at necropsy from eight patients who died over differing periods (ranging from two days to nine months) after the procedure.
main outcome measuresImmunohistochemical evaluation of smooth muscle cell phenotype modulation in relation to proliferative activity.
resultsThe earliest changes are characterised by loss of surface lining endothelial cells and insudation of blood corpuscular elements admixed with fibrin-platelet thrombus. At sites of injury vimentin positive and actin negative spindle shaped cells appear in the intima, while the related pre-existent media shows focal absence of actin positive smooth muscle cells. Proliferative activity colocalises at these sites. With time distinct neointimal thickening occurs, associated with disappearance of proliferative activity and a phenotypic shift of the smooth muscle cells.
conclusionsThe observation that luminal endothelial cell denudation, with insudation of the intima with blood elements, occurs in the very early stages suggests that these phenomena are responsible for the observed dedifferentiation of pre-existent smooth muscle cells, known to be a prerequisite for cell proliferation and the evolution of intimal thickening. It is likely, therefore, that platelet released growth factors play a pivotal role, which thus may provide a target for preventive pharmacological intervention.
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Registered trials
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