ArticleJournal of clinical microbiology2000
Heterogeneity of Actinobacillus actinomycetemcomitans strains in various human infections and relationships between serotype, genotype, and antimicrobial susceptibility.
Article in Journal of clinical microbiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 75 citations in OpenAlex.
- From Global to Nano: A Geographical Perspective ofPathogens (Basel, Switzerland) · 2024Review
- Discrepancies in Antimicrobial Susceptibility between the JP2 and the Non-JP2 Genotype ofAntibiotics (Basel, Switzerland) · 2022Article
- Herpesvirus-bacteria synergistic interaction in periodontitis.Periodontology 2000 · 2020Review
- Whole Genome Sequencing ofPathogens (Basel, Switzerland) · 2019Article
- Review
- Dental caries are positively associated with periodontal disease severity.Clinical oral investigations · 2019Article
- Article
- Phosphorylcholine is located in Aggregatibacter actinomycetemcomitans fimbrial protein Flp 1.Medical microbiology and immunology · 2018Article
- Peptidoglycan-associated lipoprotein ofJournal of oral microbiology · 2018Article
- Rheumatoid Arthritis-Associated Autoimmunity Due toFrontiers in immunology · 2018Article
- Age-related prevalence and characteristics ofJournal of oral microbiology · 2017Article
- Characterization of A. actinomycetemcomitans strains in subgingival samples from periodontitis subjects in Morocco.Clinical oral investigations · 2016Article
- Occurrence and serotype distribution of Aggregatibacter actinomycetemcomitans in subjects without periodontitis in Turkey.Archives of oral biology · 2016Article
- Mature Biofilm Degradation by Potential Probiotics: Aggregatibacter actinomycetemcomitans versus Lactobacillus spp.PloS one · 2016Article
- Leukotoxic activity of Aggregatibacter actinomycetemcomitans and periodontal attachment loss.PloS one · 2014Article
- Comparative genomic hybridization and transcriptome analysis with a pan-genome microarray reveal distinctions between JP2 and non-JP2 genotypes of Aggregatibacter actinomycetemcomitans.Molecular oral microbiology · 2013Article
- Glycosylation of the collagen adhesin EmaA of Aggregatibacter actinomycetemcomitans is dependent upon the lipopolysaccharide biosynthetic pathway.Journal of bacteriology · 2010Article
- Transcriptional and translational analysis of biofilm determinants of Aggregatibacter actinomycetemcomitans in response to environmental perturbation.Infection and immunity · 2009Article
- Functional mapping of an oligomeric autotransporter adhesin of Aggregatibacter actinomycetemcomitans.Journal of bacteriology · 2008Article
- Microevolution and patterns of dissemination of the JP2 clone of Aggregatibacter (Actinobacillus) actinomycetemcomitans.Infection and immunity · 2007Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Actinobacillus actinomycetemcomitans, an oral pathogen, only occasionally causes nonoral infections. In this study 52 A. actinomycetemcomitans strains from 51 subjects with nonoral infections were serotyped and genotyped by arbitrarily primed PCR (AP-PCR) to determine whether a certain clone(s) is specifically associated with nonoral infections or particular in vitro antimicrobial susceptibility patterns. The promoter structure of leukotoxin genes was additionally investigated to find the deletion characteristic of highly leukotoxic A. actinomycetemcomitans strains. The nonoral A. actinomycetemcomitans strains included all five known serotypes and nonserotypeable strains, the most common serotypes being b (40%) and c (31%). AP-PCR distinguished 10 different genotypes. A. actinomycetemcomitans serotype b strains were more frequently found in blood samples of patients with bacteremia or endocarditis than in patients with focal infections. One AP-PCR genotype was significantly more frequently found among strains originating in focal infections than in blood samples. Resistance to benzylpenicillin was significantly more frequent among A. actinomycetemcomitans serotype b strains than among strains of other serotypes. No differences in the leukotoxin gene promoter region or benzylpenicillin resistance between nonoral and oral A. actinomycetemcomitans strains were observed. Nonoral A. actinomycetemcomitans strains showed great similarity to the oral strains, confirming that the oral cavity is the likely source of nonoral A. actinomycetemcomitans infections. The predominance of serotype b strains in endocarditis and bacteremia supports the hypothesis of a relationship between certain A. actinomycetemcomitans clones and some nonoral infections. The mechanisms behind the exceptionally high rate of occurrence of benzylpenicillin resistance among A. actinomycetemcomitans serotype b strains are to be elucidated in further studies.
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