ArticleAnnals of surgery1999
Role of P-selectin and ICAM-1 in pancreatitis-induced lung inflammation in rats: significance of oxidative stress.
Article in Annals of surgery, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 86 citations in OpenAlex.
- Unveiling the Emerging Role of Xanthine Oxidase in Acute Pancreatitis: Beyond Reactive Oxygen Species.Antioxidants (Basel, Switzerland) · 2025Review
- Bioactive Nanomaterials: Comprehensive Monitoring and Regulation of Acute Pancreatitis Induced Acute Lung Injury.International journal of nanomedicine · 2025Review
- Inhibition of xanthine oxidase alleviated pancreatic necrosisActa pharmaceutica Sinica. B · 2024Article
- Biosensing Platform for the Detection of Biomarkers for ALI/ARDS in Bronchoalveolar Lavage Fluid of LPS Mice Model.Biosensors · 2023Article
- Role of Hydrogen Sulfide, Substance P and Adhesion Molecules in Acute Pancreatitis.International journal of molecular sciences · 2021Review
- Adhesion molecules and pancreatitis.Journal of gastroenterology · 2019Review
- Article
- New Roles for Corticosteroid Binding Globulin and Opposite Expression Profiles in Lung and Liver.PloS one · 2016Article
- Effects of Local Pancreatic Renin-Angiotensin System on the Microcirculation of Rat with Severe Acute Pancreatitis.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2015Article
- Sodium Hydrosulphide alleviates remote lung injury following limb traumatic injury in rats.PloS one · 2013Article
- Evaluation of N-acetylcysteine treatment in acute pancreatitis-induced lung injury.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
- Obese rats exhibit high levels of fat necrosis and isoprostanes in taurocholate-induced acute pancreatitis.PloS one · 2012Article
- Pancreatic and pulmonary mast cells activation during experimental acute pancreatitis.World journal of gastroenterology · 2010Article
- Alpha1G T-type calcium channel selectively regulates P-selectin surface expression in pulmonary capillary endothelium.American journal of physiology. Lung cellular and molecular physiology · 2010Article
- Influence of dexamethasone on the expression levels of P-selectin protein in multiple organs of rats with severe acute pancreatitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2010Article
- Review
- Pulmonary endothelium in acute lung injury: from basic science to the critically ill.Intensive care medicine · 2004Review
- Effect of simultaneous inhibition of TNF-alpha production and xanthine oxidase in experimental acute pancreatitis: the role of mitogen activated protein kinases.Annals of surgery · 2004Article
- Mobilization of xanthine oxidase from the gastrointestinal tract in acute pancreatitis.BMC gastroenterology · 2004Article
- Role of fibronectin in pancreatitis-associated lung injury.Digestive diseases and sciences · 2003Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the role of P-selectin and intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of lung injury associated with pancreatitis, and the relation between xanthine oxidase-derived oxidants and expression of these adhesion molecules. SUMMARY BACKGROUND DATA: In acute pancreatitis, acute respiratory distress syndrome occurs in the early stages of disease. This process is mediated by neutrophil infiltration.
methodsPancreatitis was induced in rats by intraductal administration of 5% sodium taurocholate. ICAM-1 and P-selectin expression was measured using radiolabeled monoclonal antibodies. Neutrophil infiltration and plasma levels of xanthine oxidase were also evaluated.
resultsPancreatitis induces increases in P-selectin expression in lung, whereas ICAM-1 is unchanged from baseline levels. Immunoneutralization of either P-selectin or ICAM-1 prevents the infiltration of neutrophils into the lung. Xanthine and xanthine oxidase activity were increased after induction of pancreatitis. Xanthine oxidase inhibition prevents the upregulation of P-selectin in lung and neutrophil infiltration.
conclusionsDuring acute pancreatitis, P-selectin is upregulated in the pulmonary endothelium and is a key determinant of leukocyte recruitment. Constitutive ICAM-1 is also involved in the process of cell infiltration into the lung. The increased expression of P-selectin appears to be triggered by a mechanism dependent on free radicals generated by xanthine oxidase released by the damaged pancreas.
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