ArticleThe Journal of cell biology1999
Molecular dissection of zyxin function reveals its involvement in cell motility.
Article in The Journal of cell biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 115 citations in OpenAlex.
- The Potential Link and Role of Zyxin in the Pathogenesis of Psoriasis and Its Associated Comorbidities.International journal of molecular sciences · 2026Article
- Zyxin is important for the stability and function of podocytes, especially during mechanical stretch.Communications biology · 2024Article
- The role of zyxin in signal transduction and its relationship with diseases.Frontiers in molecular biosciences · 2024Review
- Quantitative proteomic analysis of human serum using tandem mass tags to predict cardiovascular risks in patients with psoriasis.Scientific reports · 2023Article
- Synaptic branch stability is mediated by non-enzymatic functions of MEC-17/αTAT1 and ATAT-2.Scientific reports · 2022Article
- Calcium Electroporation Reduces Viability and Proliferation Capacity of Four Uveal Melanoma Cell Lines in 2D and 3D Cultures.Cancers · 2022Article
- A Layered View on Focal Adhesions.Biology · 2021Review
- Zyxin Is Involved in Fibroblast Rigidity Sensing and Durotaxis.Frontiers in cell and developmental biology · 2021Article
- Anti-Adhesion Behavior from Ring-Strain Amine Cyclic Monolayers Grafted on Silicon (111) Surfaces.Scientific reports · 2020Article
- Article
- Identification of new binding proteins of focal adhesion kinase using immunoprecipitation and mass spectrometry.Scientific reports · 2019Article
- The role of zyxin in regulation of malignancies.Heliyon · 2018Review
- Article
- Distinct focal adhesion protein modules control different aspects of mechanotransduction.Journal of cell science · 2017Article
- Delineating the Tes Interaction Site in Zyxin and Studying Cellular Effects of Its Disruption.PloS one · 2015Article
- LIM proteins in actin cytoskeleton mechanoresponse.Trends in cell biology · 2014Review
- The conserved LIM domain-containing focal adhesion protein ZYX-1 regulates synapse maintenance in Caenorhabditis elegans.Development (Cambridge, England) · 2014Article
- Rigidity-patterned polyelectrolyte films to control myoblast cell adhesion and spatial organization.Advanced functional materials · 2013Article
- Zyxin-VASP interactions alter actin regulatory activity in zyxin-VASP complexes.Cellular & molecular biology letters · 2013Article
- Stretch-induced actin remodeling requires targeting of zyxin to stress fibers and recruitment of actin regulators.Molecular biology of the cell · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Spatially controlled actin filament assembly is critical for numerous processes, including the vectorial cell migration required for wound healing, cell- mediated immunity, and embryogenesis. One protein implicated in the regulation of actin assembly is zyxin, a protein concentrated at sites where the fast growing ends of actin filaments are enriched. To evaluate the role of zyxin in vivo, we developed a specific peptide inhibitor of zyxin function that blocks its interaction with alpha-actinin and displaces it from its normal subcellular location. Mislocalization of zyxin perturbs cell migration and spreading, and affects the behavior of the cell edge, a structure maintained by assembly of actin at sites proximal to the plasma membrane. These results support a role for zyxin in cell motility, and demonstrate that the correct positioning of zyxin within the cell is critical for its physiological function. Interestingly, the mislocalization of zyxin in the peptide-injected cells is accompanied by disturbances in the distribution of Ena/VASP family members, proteins that have a well-established role in promoting actin assembly. In concert with previous work, our findings suggest that zyxin promotes the spatially restricted assembly of protein complexes necessary for cell motility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.