ArticleGenome research1999
Perfect conserved linkage across the entire mouse chromosome 10 region homologous to human chromosome 21.
Article in Genome research, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome.Blood · 2009Review
- A comprehensive mouse IBD database for the efficient localization of quantitative trait loci.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
- Genomic analysis of a 1 Mb region near the telomere of Hessian fly chromosome X2 and avirulence gene vH13.BMC genomics · 2006Article
- Evolutionarily conserved sequences on human chromosome 21.Genome research · 2001Article
- Chromosome evolution: the junction of mammalian chromosomes in the formation of mouse chromosome 10.Genome research · 2000Article
- Comparative maps of human 19p13.3 and mouse chromosome 10 allow identification of sequences at evolutionary breakpoints.Genome research · 2000Article
- Current awareness.Yeast (Chichester, England) · 2000Article
- The sequence of human chromosome 21 and implications for research into Down syndrome.Genome biology · 2000Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The distal end of human Chromosome (HSA) 21 from PDXK to the telomere shows perfect conserved linkage with mouse Chromosome (MMU) 10. This region is bounded on the proximal side by a segment of homology to HSA22q11.2, and on the distal side by a region of homology with HSA19p13.1. A high-resolution PAC-based physical map is described that spans 2.8 Mb, including the entire 2.1 Mb from Pdxk to Prmt2 corresponding to HSA21. Thirty-four expressed sequences are mapped, three of which were not mapped previously in any species and nine more that are mapped in mouse for the first time. These genes confirm and extend the conserved linkage between MMU10 and HSA21. The ordered PACs and dense STS map provide a clone resource for biological experiments, for rapid and accurate mapping, and for genomic sequencing. The new genes identified here may be involved in Down syndrome (DS) or in several genetic diseases that map to this conserved region of HSA21.
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Registered trials
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