ArticleGenome research1999
Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication.
Article in Genome research, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 65 citations in OpenAlex.
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- Transcriptional Regulation of the Synaptic Vesicle Protein Synaptogyrin-3 (International journal of molecular sciences · 2022Article
- Proteomic and Transcriptomic Analyses Reveal Pathological Changes in the Entorhinal Cortex Region that Correlate Well with Dysregulation of Ion Transport in Patients with Alzheimer's Disease.Molecular neurobiology · 2021Article
- Transcriptome Analysis Reveals the Role of Cellular Calcium Disorder in Varicella Zoster Virus-Induced Post-Herpetic Neuralgia.Frontiers in molecular neuroscience · 2021Article
- Amplification of a calcium channel subunit CACNG4 increases breast cancer metastasis.EBioMedicine · 2020Article
- Synthesis, pharmacology and preclinical evaluation ofEuropean journal of medicinal chemistry · 2018Article
- Identify Down syndrome transcriptome associations using integrative analysis of microarray database and correlation-interaction network.Human genomics · 2018Article
- Different Profile of mRNA Expression in Sinoatrial Node from Streptozotocin-Induced Diabetic Rat.PloS one · 2016Article
- Structure-function of proteins interacting with the α1 pore-forming subunit of high-voltage-activated calcium channels.Frontiers in physiology · 2014Review
- The expanding social network of ionotropic glutamate receptors: TARPs and other transmembrane auxiliary subunits.Neuron · 2011Review
- Regulation of ionotropic glutamate receptors by their auxiliary subunits.Physiology (Bethesda, Md.) · 2010Review
- Transmembrane AMPA receptor regulatory proteins and AMPA receptor function in the cerebellum.Neuroscience · 2009Review
- The gamma subunit runs in the family.The Journal of physiology · 2008Article
- The stargazin-related protein gamma 7 interacts with the mRNA-binding protein heterogeneous nuclear ribonucleoprotein A2 and regulates the stability of specific mRNAs, including CaV2.2.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Localization and mutation detection for paroxysmal kinesigenic choreoathetosis.Journal of molecular neuroscience : MN · 2008Article
- Stargazin and other transmembrane AMPA receptor regulating proteins interact with synaptic scaffolding protein MAGI-2 in brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- The alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate receptor trafficking regulator "stargazin" is related to the claudin family of proteins by Its ability to mediate cell-cell adhesion.The Journal of biological chemistry · 2005Article
- Stargazin reduces desensitization and slows deactivation of the AMPA-type glutamate receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- A targeted mutation in Cacng4 exacerbates spike-wave seizures in stargazer (Cacng2) mice.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- The voltage-gated calcium channel gamma subunits: a review of the literature.Journal of bioenergetics and biomembranes · 2003Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Gene duplication is believed to be an important evolutionary mechanism for generating functional diversity within genomes. The accumulated products of ancient duplication events can be readily observed among the genes encoding voltage-dependent Ca(2+) ion channels. Ten paralogous genes have been identified that encode isoforms of the alpha(1) subunit, four that encode beta subunits, and three that encode alpha(2)delta subunits. Until recently, only a single gene encoding a muscle-specific isoform of the Ca(2+) channel gamma subunit (CACNG1) was known. Expression of a distantly related gene in the brain was subsequently demonstrated upon isolation of the Cacng2 gene, which is mutated in the mouse neurological mutant stargazer (stg). In this study, we sought to identify additional genes that encoded gamma subunits. Because gene duplication often generates paralogs that remain in close syntenic proximity (tandem duplication) or are copied onto related daughter chromosomes (chromosome or whole-genome duplication), we hypothesized that the known positions of CACNG1 and CACNG2 could be used to predict the likely locations of additional gamma subunit genes. Low-stringency genomic sequence analysis of targeted regions led to the identification of three novel Ca(2+) channel gamma subunit genes, CACNG3, CACNG4, and CACNG5, on chromosomes 16 and 17. These results demonstrate the value of genome evolution models for the identification of distantly related members of gene families.
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