ArticleGenome research1999
Prediction of gene function by genome-scale expression analysis: prostate cancer-associated genes.
Article in Genome research, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it, 172 citations in OpenAlex.
- Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits.PLoS genetics · 2020Pooled it
- Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population.Human genetics · 2013Trial
- Artificial Intelligence for Plant Gene Regulatory Networks.International journal of molecular sciences · 2026Review
- Triclustering Model for Three-Dimensional Time-Series Gene Expression Data.International journal of molecular sciences · 2026Article
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- Screening Indels from the whole genome to identify the candidates and their association with economic traits in several goat breeds.Functional & integrative genomics · 2023Article
- PANDA2: protein function prediction using graph neural networks.NAR genomics and bioinformatics · 2022Article
- Identification and characterization of proteins of unknown function (PUFs) in Clostridium thermocellum DSM 1313 strains as potential genetic engineering targets.Biotechnology for biofuels · 2021Article
- Nanopore long-read RNA-seq and absolute quantification delineate transcription dynamics in early embryo development of an insect pest.Scientific reports · 2021Article
- The evolutionary conserved iron-sulfur protein TCR controls P700 oxidation in photosystem I.iScience · 2021Article
- Transfer of oral bacteria to the fetus during late gestation.Scientific reports · 2021Article
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- HpeNet: Co-expression Network Database forFrontiers in genetics · 2020Article
- Recapitulation of prostate tissue cell type-specific transcriptomes by an in vivo primary prostate tissue xenograft model.PloS one · 2020Article
- Molecular architecture of lineage allocation and tissue organization in early mouse embryo.Nature · 2019Article
- Discovery and characterization of functional modules associated with body weight in broilers.Scientific reports · 2019Article
- Exploration of gene functions for esophageal squamous cell carcinoma using network-based guilt by association principle.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2018Article
- Clustering gene expression time series data using an infinite Gaussian process mixture model.PLoS computational biology · 2018Article
- Transcriptome analysis reveals determinant stages controlling human embryonic stem cell commitment to neuronal cells.The Journal of biological chemistry · 2017Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We wish to identify genes associated with disease. To do so, we look for novel genes whose expression patterns mimic those of known disease-associated genes, using a method we call Guilt-by-Association (GBA), on the basis of a combinatoric measure of association. Using GBA, we have examined the expression of 40,000 human genes in 522 cDNA libraries, and have discovered several hundred previously unidentified genes associated with cancer, inflammation, steroid-synthesis, insulin-synthesis, neurotransmitter processing, matrix remodeling, and other disease processes. The majority of the genes thus discovered show no sequence similarity to known genes, and thus could not have been identified by homology searches. We present here an example of the discovery of eight genes associated with prostate cancer. Of the 40,000 most-abundant human genes, these 8 are the most closely linked to the known diagnostic genes, and thus are prime targets for pharmaceutical research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.