ReviewGlycoconjugate journal1999
Filamentous fungi as production organisms for glycoproteins of bio-medical interest.
Review in Glycoconjugate journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- Protein secretion and associated stress in industrially employed filamentous fungi.Applied microbiology and biotechnology · 2024Review
- Large-Scale Production of Anti-RNase A VHH Expressed inCurrent issues in molecular biology · 2023Article
- Magnaporthe oryzae as an expression host for the production of the unspecific peroxygenase AaeUPO from the basidiomycete Agrocybe aegerita.MicrobiologyOpen · 2021Article
- Biopharmaceuticals from microorganisms: from production to purification.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2016Review
- Genome sequence of Aspergillus luchuensis NBRC 4314.DNA research : an international journal for rapid publication of reports on genes and genomes · 2016Article
- Mapping N-linked glycosylation of carbohydrate-active enzymes in the secretome of Aspergillus nidulans grown on lignocellulose.Biotechnology for biofuels · 2016Article
- Making recombinant proteins in filamentous fungi- are we expecting too much?Frontiers in microbiology · 2014Review
- Proteomic analysis of ripening tomato fruit infected by Botrytis cinerea.Journal of proteome research · 2012Article
- Approaching the secrets of N-glycosylation in Aspergillus fumigatus: characterization of the AfOch1 protein.PloS one · 2010Article
- Production of the Aspergillus aculeatus endo-1,4-beta-mannanase in A. niger.Journal of industrial microbiology & biotechnology · 2009Article
- Cellulase production from spent lignocellulose hydrolysates by recombinant Aspergillus niger.Applied and environmental microbiology · 2009Article
- Production, purification, and characterization of human alpha1 proteinase inhibitor from Aspergillus niger.Biotechnology and bioengineering · 2009Article
- Contribution of galactofuranose to the virulence of the opportunistic pathogen Aspergillus fumigatus.Eukaryotic cell · 2008Article
- Expression of human alpha1-proteinase inhibitor in Aspergillus niger.Microbial cell factories · 2007Article
- Galactomannoproteins of Aspergillus fumigatus.Eukaryotic cell · 2005Article
- Appropriate glycosylation of recombinant proteins for human use: implications of choice of expression system.Molecular biotechnology · 2004Review
- Characterization of humanized antibodies secreted by Aspergillus niger.Applied and environmental microbiology · 2004Article
- A novel saponin hydrolase from Neocosmospora vasinfecta var. vasinfecta.Applied and environmental microbiology · 2004Article
- The production of antibody fragments and antibody fusion proteins by yeasts and filamentous fungi.Microbial cell factories · 2003Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Filamentous fungi are commonly used in the fermentation industry for large scale production of glycoproteins. Several of these proteins can be produced in concentrations up to 20-40 g per litre. The production of heterologous glycoproteins is at least one or two orders of magnitude lower but research is in progress to increase the production levels. In the past years the structure of protein-linked carbohydrates of a number of fungal proteins has been elucidated, showing the presence of oligo-mannosidic and high-mannose chains, sometimes with typical fungal modifications. A start has been made to engineer the glycosylation pathway in filamentous fungi to obtain strains that show a more mammalian-like type of glycosylation. This mini review aims to cover the current knowledge of glycosylation in filamentous fungi, and to show the possibilities to produce glycoproteins with these organisms with a more mammalian-like type of glycosylation for research purposes or pharmaceutical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.