ArticleProceedings of the National Academy of Sciences of the United States of America1999
Alternative splicing, muscle calcium sensitivity, and the modulation of dragonfly flight performance.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 51 citations in OpenAlex.
- Role of the interaction between troponin T and AMP deaminase by zinc bridge in modulating muscle contraction and ammonia production.Molecular and cellular biochemistry · 2024Review
- Transcriptomic analysis of the trade-off between endurance and burst-performance in the frog Xenopus allofraseri.BMC genomics · 2021Article
- Evolution of Flight Muscle Contractility and Energetic Efficiency.Frontiers in physiology · 2020Review
- Extensive Differential Splicing Underlies Phenotypically Plastic Aphid Morphs.Molecular biology and evolution · 2018Article
- Molecular plasticity and functional enhancements of leg muscles in response to hypergravity in the fruit flyThe Journal of experimental biology · 2017Article
- Effects of age and hindlimb immobilization and remobilization on fast troponin T precursor mRNA alternative splicing in rat gastrocnemius muscle.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2016Article
- Effects of ambient and preceding temperatures and metabolic genes on flight metabolism in the Glanville fritillary butterfly.Journal of insect physiology · 2016Article
- Regulating the contraction of insect flight muscle.Journal of muscle research and cell motility · 2011Review
- Body weight-dependent troponin T alternative splicing is evolutionarily conserved from insects to mammals and is partially impaired in skeletal muscle of obese rats.The Journal of experimental biology · 2011Article
- The effects of age and behavioral development on honey bee (Apis mellifera) flight performance.The Journal of experimental biology · 2009Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium sensitivity of myosin cross-bridge activation in striated muscles commonly varies during ontogeny and in response to alterations in muscle usage, but the consequences for whole-organism physiology are not well known. Here we show that the relative abundances of alternatively spliced transcripts of the calcium regulatory protein troponin T (TnT) vary widely in flight muscle of Libellula pulchella dragonflies, and that the mixture of TnT splice variants explains significant portions of the variation in muscle calcium sensitivity, wing-beat frequency, and an index of aerodynamic power output during free flight. Two size-distinguishable morphs differ in their maturational pattern of TnT splicing, yet they show the same relationship between TnT transcript mixture and calcium sensitivity and between calcium sensitivity and aerodynamic power output. This consistency of effect in different developmental and physiological contexts strengthens the hypothesis that TnT isoform variation modulates muscle calcium sensitivity and whole-organism locomotor performance. Modulating muscle power output appears to provide the ecologically important ability to operate at different points along a tradeoff between performance and energetic cost.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.