ArticleProceedings of the National Academy of Sciences of the United States of America1999
Neuronal calcium sparks and intracellular calcium "noise".
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- On the genesis and unique functions of zinc neuromodulation.Journal of neurophysiology · 2024Review
- Theory and applications of geometric scaling of localized calcium release events.American journal of physiology. Cell physiology · 2010Article
- Calicum microdomains form within neutrophils at the neutrophil-tumor cell synapse: role in antibody-dependent target cell apoptosis.Cancer immunology, immunotherapy : CII · 2010Article
- Dihydropyridine receptors and type 1 ryanodine receptors constitute the molecular machinery for voltage-induced Ca2+ release in nerve terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Analysis of puff dynamics in oocytes: interdependence of puff amplitude and interpuff interval.Biophysical journal · 2006Article
- Ca2+ sparks and secretion in dorsal root ganglion neurons.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Ca2+ syntillas, miniature Ca2+ release events in terminals of hypothalamic neurons, are increased in frequency by depolarization in the absence of Ca2+ influx.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Stochastic properties of Ca(2+) release of inositol 1,4,5-trisphosphate receptor clusters.Biophysical journal · 2002Article
- Cerebellar neurons lacking complex gangliosides degenerate in the presence of depolarizing levels of potassium.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
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4 authors.
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Abstract
Intracellular calcium ions are involved in many forms of cellular function. To accommodate so many control functions, a complex spatiotemporal organization of calcium signaling has developed. In both excitable and nonexcitable cells, calcium signaling was found to fluctuate. Sudden localized increases in the intracellular calcium concentration-or calcium sparks-were found in heart, striated and smooth muscle, Xenopus Laevis oocytes, and HeLa and P12 cells. In the nervous system, intracellular calcium ions were found important in key processes such as transmitter release, repetitive firing, and gene expression. Hence, we examined whether calcium sparks also exist in neurons. Using confocal laser-scanning microscopy and fluorescent probes, we found that calcium sparks exist in two types of neuronal preparations: the presynaptic boutons of the lizard neuromuscular junction and rat hippocampal neurons in cell culture. Control experiments exclude the possibility that these calcium sparks originate from instrumental or biological artifacts. Calcium sparks seem to be just the tip of the iceberg of a more general phenomenon of intracellular calcium "noise." We speculate that calcium sparks and calcium noise may be of key importance in calcium signaling in the nervous system.
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