ArticleProceedings of the National Academy of Sciences of the United States of America1999
Antigen-driven CD4+ T cell and HIV-1 dynamics: residual viral replication under highly active antiretroviral therapy.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- A stochastic model of latently infected cell reactivation and viral blip generation in treated HIV patients.PLoS computational biology · 2011Article
- Modeling latently infected cell activation: viral and latent reservoir persistence, and viral blips in HIV-infected patients on potent therapy.PLoS computational biology · 2009Article
- Modeling HIV persistence, the latent reservoir, and viral blips.Journal of theoretical biology · 2009Review
- Asymmetric division of activated latently infected cells may explain the decay kinetics of the HIV-1 latent reservoir and intermittent viral blips.Mathematical biosciences · 2009Article
- Transient viremia, plasma viral load, and reservoir replenishment in HIV-infected patients on antiretroviral therapy.Journal of acquired immune deficiency syndromes (1999) · 2007Article
- Modelling the human immune system by combining bioinformatics and systems biology approaches.Journal of biological physics · 2006Article
- Role of avidity and breadth of the CD4 T cell response in progression to AIDS.Proceedings. Biological sciences · 2006Article
- Adherence to antiretroviral therapy and its impact on clinical outcome in HIV-infected patients.Journal of the Royal Society, Interface · 2005Article
- The epidemiological impact of antiretroviral use predicted by mathematical models: a review.Emerging themes in epidemiology · 2005Article
- Subpopulations of long-lived and short-lived T cells in advanced HIV-1 infection.The Journal of clinical investigation · 2003Article
- Decelerating decay of latently infected cells during prolonged therapy for human immunodeficiency virus type 1 infection.Journal of virology · 2002Article
- Quantification of intrinsic residual viral replication in treated HIV-infected patients.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- The role of antigenic stimulation and cytotoxic T cell activity in regulating the long-term immunopathogenesis of HIV: mechanisms and clinical implications.Proceedings. Biological sciences · 2001Review
- T-cell re-population in HIV-infected children on highly active anti-retroviral therapy (HAART).Clinical and experimental immunology · 2001Article
- Release of virus from lymphoid tissue affects human immunodeficiency virus type 1 and hepatitis C virus kinetics in the blood.Journal of virology · 2001Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Antigen-induced stimulation of the immune system can generate heterogeneity in CD4+ T cell division rates capable of explaining the temporal patterns seen in the decay of HIV-1 plasma RNA levels during highly active antiretroviral therapy. Posttreatment increases in peripheral CD4+ T cell counts are consistent with a mathematical model in which host cell redistribution between lymph nodes and peripheral blood is a function of viral burden. Model fits to patient data suggest that, although therapy reduces HIV replication below replacement levels, substantial residual replication continues. This residual replication has important consequences for long-term therapy and the evolution of drug resistance and represents a challenge for future treatment strategies.
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