ArticleProceedings of the National Academy of Sciences of the United States of America1999
A novel multigene family encodes diversified variable regions.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed, 95 citations in OpenAlex.
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- On Origin and Evolution of the Antibody Molecule.Biology · 2021Review
- Spotted Gar and the Evolution of Innate Immune Receptors.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2017Article
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- Multigene families of immunoglobulin domain-containing innate immune receptors in zebrafish: deciphering the differences.Developmental and comparative immunology · 2014Review
- Diversity of CD2 subfamily receptors in cyprinid fishes.Results in immunology · 2012Article
- The phylogenetic origins of natural killer receptors and recognition: relationships, possibilities, and realities.Immunogenetics · 2011Review
- Genomic organisation analysis of novel immunoglobulin-like transcripts in Atlantic salmon (Salmo salar) reveals a tightly clustered and multigene family.BMC genomics · 2010Article
- Antibody dependent enhancement of frog virus 3 infection.Virology journal · 2010Article
- Recognition of additional roles for immunoglobulin domains in immune function.Seminars in immunology · 2010Review
- Developmental and tissue-specific expression of NITRs.Immunogenetics · 2010Article
- Article
- A bony fish immunological receptor of the NITR multigene family mediates allogeneic recognition.Immunity · 2008Article
- The medaka novel immune-type receptor (NITR) gene clusters reveal an extraordinary degree of divergence in variable domains.BMC evolutionary biology · 2008Article
- Evidence for a transposition event in a second NITR gene cluster in zebrafish.Immunogenetics · 2008Article
- B cell receptor accessory molecules in the channel catfish, Ictalurus punctatus.Developmental and comparative immunology · 2008Article
- Crystallization and X-ray diffraction analysis of a novel immune-type receptor from Ictalurus punctatus and phasing by selenium anomalous dispersion methods.Acta crystallographica. Section F, Structural biology and crystallization communications · 2007Article
- The zebrafish activating immune receptor Nitr9 signals via Dap12.Immunogenetics · 2007Article
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9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antigen recognition in the adaptive immune response by Ig and T-cell antigen receptors (TCRs) is effected through patterned differences in the peptide sequence in the V regions. V-region specificity forms through genetically programmed rearrangement of individual, diversified segmental elements in single somatic cells. Other Ig superfamily members, including natural killer receptors that mediate cell-surface recognition, do not undergo segmental reorganization, and contain type-2 C (C2) domains, which are structurally distinct from the C1 domains found in Ig and TCR. Immunoreceptor tyrosine-based inhibitory motifs that transduce negative regulatory signals through the cell membrane are found in certain natural killer and other cell surface inhibitory receptors, but not in Ig and TCR. In this study, we employ a genomic approach by using the pufferfish (Spheroides nephelus) to characterize a nonrearranging novel immune-type receptor gene family. Twenty-six different nonrearranging genes, which each encode highly diversified V as well as a V-like C2 extracellular domain, a transmembrane region, and in most instances, an immunoreceptor tyrosine-based inhibitory motif-containing cytoplasmic tail, are identified in an approximately 113 kb P1 artificial chromosome insert. The presence in novel immune-type receptor genes of V regions that are related closely to those found in Ig and TCR as well as regulatory motifs that are characteristic of inhibitory receptors implies a heretofore unrecognized link between known receptors that mediate adaptive and innate immune functions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.