ArticleProceedings of the National Academy of Sciences of the United States of America1999
Varying the number of telomere-bound proteins does not alter telomere length in tel1Delta cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Telomere shortening causes distinct cell division regimes during replicative senescence in Saccharomyces cerevisiae.Cell & bioscience · 2021Article
- At short telomeres Tel1 directs early replication and phosphorylates Rif1.PLoS genetics · 2014Article
- Everything you ever wanted to know about Saccharomyces cerevisiae telomeres: beginning to end.Genetics · 2012Review
- Mec1p associates with functionally compromised telomeres.Chromosoma · 2012Article
- The budding yeast nucleus.Cold Spring Harbor perspectives in biology · 2010Review
- Deletion of Ogg1 DNA glycosylase results in telomere base damage and length alteration in yeast.The EMBO journal · 2010Article
- Telomere length regulation: coupling DNA end processing to feedback regulation of telomerase.The EMBO journal · 2009Review
- Tel1 kinase and subtelomere-bound Tbf1 mediate preferential elongation of short telomeres by telomerase in yeast.EMBO reports · 2007Article
- Subtelomeric factors antagonize telomere anchoring and Tel1-independent telomere length regulation.The EMBO journal · 2006Article
- Subtelomeric proteins negatively regulate telomere elongation in budding yeast.The EMBO journal · 2006Article
- Ataxia telangiectasia mutated (Atm) is not required for telomerase-mediated elongation of short telomeres.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Regulation of telomere length by an N-terminal region of the yeast telomerase reverse transcriptase.Molecular and cellular biology · 2005Article
- Making the most of a little: dosage effects in eukaryotic telomere length maintenance.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2005Review
- Pol12, the B subunit of DNA polymerase alpha, functions in both telomere capping and length regulation.Genes & development · 2004Article
- Sudden telomere lengthening triggers a Rad53-dependent checkpoint in Saccharomyces cerevisiae.Molecular biology of the cell · 2003Article
- The number of vertebrate repeats can be regulated at yeast telomeres by Rap1-independent mechanisms.The EMBO journal · 2003Article
- MEC3, MEC1, and DDC2 are essential components of a telomere checkpoint pathway required for cell cycle arrest during senescence in Saccharomyces cerevisiae.Molecular biology of the cell · 2002Article
- Yeast telomerase appears to frequently copy the entire template in vivo.Nucleic acids research · 2001Article
- Cdc13 cooperates with the yeast Ku proteins and Stn1 to regulate telomerase recruitment.Molecular and cellular biology · 2000Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Yeast telomere DNA consists of a continuous, approximately 330-bp tract of the heterogeneous repeat TG(1-3) with irregularly spaced, high affinity sites for the protein Rap1p. Yeast monitor, or count, the number of telomeric Rap1p C termini in a negative feedback mechanism to modulate the length of the terminal TG(1-3) repeats, and synthetic telomeres that tether Rap1p molecules adjacent to the TG(1-3) tract cause wild-type cells to maintain a shorter TG(1-3) tract. To identify trans-acting proteins required to count Rap1p molecules, these same synthetic telomeres were placed in two short telomere mutants: yku70Delta (which lack the yeast Ku70 protein) and tel1Delta (which lack the yeast ortholog of ATM). Although both mutants maintain telomeres with approximately 100 bp of TG(1-3), only yku70Delta cells maintained shorter TG(1-3) repeats in response to internal Rap1p molecules. This distinct response to internal Rap1p molecules was not caused by a variation in Rap1p site density in the TG(1-3) repeats as sequencing of tel1Delta and yku70Delta telomeres showed that both strains have only five to six Rap1p sites per 100-bp telomere. In addition, the tel1Delta short telomere phenotype was epistatic to the unregulated telomere length caused by deletion of the Rap1p C-terminal domain. Thus, the length of the TG(1-3) repeats in tel1Delta cells was independent of the number of the Rap1p C termini at the telomere. These data indicate that tel1Delta cells use an alternative mechanism to regulate telomere length that is distinct from monitoring the number of telomere binding proteins.
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