ArticleProceedings of the National Academy of Sciences of the United States of America1999
A subset of skin tumor modifier loci determines survival time of tumor-bearing mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 76 citations in OpenAlex.
- The Anti-Tumorigenic Role of Cannabinoid Receptor 2 in Non-Melanoma Skin Cancer.International journal of molecular sciences · 2023Article
- A wild-derived inbred mouse strain, MSM/Ms, provides insights into novel skin tumor susceptibility genes.Experimental animals · 2021Article
- Germline Variants Impact Somatic Events during Tumorigenesis.Trends in genetics : TIG · 2019Review
- Mapping of new skin tumor susceptibility loci by a phenotype-driven congenic approach.Oncology letters · 2018Article
- Panx3 links body mass index and tumorigenesis in a genetically heterogeneous mouse model of carcinogen-induced cancer.Genome medicine · 2016Article
- Fine mapping reveals that promotion susceptibility locus 1 (Psl1) is a compound locus with multiple genes that modify susceptibility to skin tumor development.G3 (Bethesda, Md.) · 2014Article
- Allele-specific imbalance mapping identifies HDAC9 as a candidate gene for cutaneous squamous cell carcinoma.International journal of cancer · 2014Article
- Schistosoma mansoni experimental infection in Mus spretus (SPRET/EiJ strain) mice.Parasite (Paris, France) · 2013Article
- Proteomic and pathway analyses reveal a network of inflammatory genes associated with differences in skin tumor promotion susceptibility in DBA/2 and C57BL/6 mice.Carcinogenesis · 2012Article
- Common polymorphisms in angiogenesis.Cold Spring Harbor perspectives in medicine · 2012Review
- Allele-specific deletions in mouse tumors identify Fbxw7 as germline modifier of tumor susceptibility.PloS one · 2012Article
- Cancer evolution and individual susceptibility.Integrative biology : quantitative biosciences from nano to macro · 2011Review
- Most lung and colon cancer susceptibility genes are pair-wise linked in mice, humans and rats.PloS one · 2011Article
- New outbred colony derived from Mus musculus castaneus to identify skin tumor susceptibility loci.Molecular carcinogenesis · 2010Article
- Sequence divergence of Mus spretus and Mus musculus across a skin cancer susceptibility locus.BMC genomics · 2008Article
- Modeling cancer patient populations in mice: complex genetic and environmental factors.Drug discovery today. Disease models · 2008Article
- New chemically induced skin tumour susceptibility loci identified in a mouse backcross between FVB and dominant resistant PWK.BMC genetics · 2007Article
- Article
- Genetic background influences murine prostate gene expression: implications for cancer phenotypes.Genome biology · 2007Article
- Genetic control of the spontaneous activation of CD4+ Th cells in systemic lupus erythematosus-prone (NZB x NZW) F1 mice.Genes and immunity · 2006Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies of mouse models of human cancer have established the existence of multiple tumor modifiers that influence parameters of cancer susceptibility such as tumor multiplicity, tumor size, or the probability of malignant progression. We have carried out an analysis of skin tumor susceptibility in interspecific Mus musculus/Mus spretus hybrid mice and have identified another seven loci showing either significant (six loci) or suggestive (one locus) linkage to tumor susceptibility or resistance. A specific search was carried out for skin tumor modifier loci associated with time of survival after development of a malignant tumor. A combination of resistance alleles at three markers [D6Mit15 (Skts12), D7Mit12 (Skts2), and D17Mit7 (Skts10)], all of which are close to or the same as loci associated with carcinoma incidence and/or papilloma multiplicity, is significantly associated with increased survival of mice with carcinomas, whereas the reverse combination of susceptibility alleles is significantly linked to early mortality caused by rapid carcinoma growth (chi(2) = 25.22; P = 5.1 x 10(-8)). These data indicate that host genetic factors may be used to predict carcinoma growth rate and/or survival of individual backcross mice exposed to the same carcinogenic stimulus and suggest that mouse models may provide an approach to the identification of genetic modifiers of cancer survival in humans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.