ArticleProceedings of the National Academy of Sciences of the United States of America1999
Major recent and independent changes in levels and patterns of expression have occurred at the b gene, a regulatory locus in maize.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- Regulation of Flavonoid Biosynthesis by the MYB-bHLH-WDR (MBW) Complex in Plants and Its Specific Features in Cereals.International journal of molecular sciences · 2025Review
- The double flower variant of yellowhorn is due to a LINE1 transposon-mediated insertion.Plant physiology · 2023Article
- Demonstration of local adaptation in maize landraces by reciprocal transplantation.Evolutionary applications · 2022Article
- A B73×Palomero Toluqueño mapping population reveals local adaptation in Mexican highland maize.G3 (Bethesda, Md.) · 2022Article
- Genome-wide association study of traits in sacred lotus uncovers MITE-associated variants underlying stamen petaloid and petal number variations.Frontiers in plant science · 2022Article
- Overexpression of Maize ZmC1 and ZmR Transcription Factors in Wheat Regulates Anthocyanin Biosynthesis in a Tissue-Specific Manner.International journal of molecular sciences · 2019Article
- Article
- Two transcription factors TaPpm1 and TaPpb1 co-regulate anthocyanin biosynthesis in purple pericarps of wheat.Journal of experimental botany · 2018Article
- Diverse gene-silencing mechanisms with distinct requirements for RNA polymerase subunits in Zea mays.Genetics · 2014Article
- Unraveling the mechanism underlying the glycosylation and methylation of anthocyanins in peach.Plant physiology · 2014Article
- How important are transposons for plant evolution?Nature reviews. Genetics · 2013Review
- Molecular genetic basis of pod corn (Tunicate maize).Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Genetic and molecular analysis of a purple sheath somaclonal mutant in japonica rice.Plant cell reports · 2011Article
- Evolution of transcription factor binding sites in mammalian gene regulatory regions: handling counterintuitive results.Journal of molecular evolution · 2009Article
- Tissue- and expression level-specific chromatin looping at maize b1 epialleles.The Plant cell · 2009Article
- Assessing the efficiency of RNA interference for maize functional genomics.Plant physiology · 2007Article
- Article
- Nucleotide diversity of the ZmPox3 maize peroxidase gene: relationships between a MITE insertion in exon 2 and variation in forage maize digestibility.BMC genetics · 2004Article
- Candidate gene analysis of anthocyanin pigmentation loci in the Solanaceae.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2004Article
- SNP frequency, haplotype structure and linkage disequilibrium in elite maize inbred lines.BMC genetics · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The b locus encodes a transcription factor that regulates the expression of genes that produce purple anthocyanin pigment. Different b alleles are expressed in distinct tissues, causing tissue-specific anthocyanin production. Understanding how phenotypic diversity is produced and maintained at the b locus should provide models for how other regulatory genes, including those that influence morphological traits and development, evolve. We have investigated how different levels and patterns of pigmentation have evolved by determining the phenotypic and evolutionary relationships between 18 alleles that represent the diversity of b alleles in Zea mays. Although most of these alleles have few phenotypic differences, five alleles have very distinct tissue-specific patterns of pigmentation. Superimposing the phenotypes on the molecular phylogeny reveals that the alleles with strong and distinctive patterns of expression are closely related to alleles with weak expression, implying that the distinctive patterns have arisen recently. We have identified apparent insertions in three of the five phenotypically distinct alleles, and the fourth has unique upstream restriction fragment length polymorphisms relative to closely related alleles. The insertion in B-Peru has been shown to be responsible for its unique expression and, in the other two alleles, the presence of the insertion correlates with the phenotype. These results suggest that major changes in gene expression are probably the result of large-scale changes in DNA sequence and/or structure most likely mediated by transposable elements.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.