ArticleProceedings of the National Academy of Sciences of the United States of America1999
Dissociation of HIV-1 from follicular dendritic cells during HAART: mathematical analysis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 74 citations in OpenAlex.
- Lymphoid B cells upregulate HIV-1 ex vivo and are linked to its expression in vivo.PLoS pathogens · 2025Article
- Modeling the Interplay Between Viral and Immune Dynamics in HIV: A Review and Mrgsolve Implementation and Exploration.Clinical and translational science · 2025Review
- Acute hepatitis B virus infection in humanized chimeric mice has multiphasic viral kinetics.Hepatology (Baltimore, Md.) · 2018Article
- How Germinal Centers Evolve Broadly Neutralizing Antibodies: the Breadth of the Follicular Helper T Cell Response.Journal of virology · 2017Article
- Modeling the within-host dynamics of HIV infection.BMC biology · 2013Review
- Contribution of follicular dendritic cells to persistent HIV viremia.Journal of virology · 2013Article
- Receptor concentration and diffusivity control multivalent binding of Sv40 to membrane bilayers.PLoS computational biology · 2013Article
- HIV infection: what should be considered in approaches for a cure?AIDS (London, England) · 2012Article
- A detailed mathematical model predicts that serial engagement of IgE-Fc epsilon RI complexes can enhance Syk activation in mast cells.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Current estimates for HIV-1 production imply rapid viral clearance in lymphoid tissues.PLoS computational biology · 2010Article
- Modeling HIV persistence, the latent reservoir, and viral blips.Journal of theoretical biology · 2009Review
- Viral and latent reservoir persistence in HIV-1-infected patients on therapy.PLoS computational biology · 2006Article
- The effect of cellular receptor diffusion on receptor-mediated viral binding using Brownian adhesive dynamics (BRAD) simulations.Biophysical journal · 2005Article
- Brownian adhesive dynamics (BRAD) for simulating the receptor-mediated binding of viruses.Biophysical journal · 2004Article
- Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: intrinsic stability predicts lifelong persistence.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- In a subset of subjects on highly active antiretroviral therapy, human immunodeficiency virus type 1 RNA in plasma decays from 50 to <5 copies per milliliter, with a half-life of 6 months.Journal of virology · 2003Article
- Human immunodeficiency virus type 1 bound to B cells: relationship to virus replicating in CD4+ T cells and circulating in plasma.Journal of virology · 2002Article
- HIV Eradication: Progress and Challenges.Ochsner journal · 2001Article
- Release of virus from lymphoid tissue affects human immunodeficiency virus type 1 and hepatitis C virus kinetics in the blood.Journal of virology · 2001Article
- Influence of follicular dendritic cells on decay of HIV during antiretroviral therapy.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Follicular dendritic cells (FDC) provide a reservoir for HIV type 1 (HIV-1) that may reignite infection if highly active antiretroviral therapy (HAART) is withdrawn before virus on FDC is cleared. To estimate the treatment time required to eliminate HIV-1 on FDC, we develop deterministic and stochastic models for the reversible binding of HIV-1 to FDC via ligand-receptor interactions and examine the consequences of reducing the virus available for binding to FDC. Analysis of these models shows that the rate at which HIV-1 dissociates from FDC during HAART is biphasic, with an initial period of rapid decay followed by a period of slower exponential decay. The speed of the slower second stage of dissociation and the treatment time required to eradicate the FDC reservoir of HIV-1 are insensitive to the number of virions bound and their degree of attachment to FDC before treatment. In contrast, the expected time required for dissociation of an individual virion from FDC varies sensitively with the number of ligands attached to the virion that are available to interact with receptors on FDC. Although most virions may dissociate from FDC on the time scale of days to weeks, virions coupled to a higher-than-average number of ligands may persist on FDC for years. This result suggests that HAART may not be able to clear all HIV-1 trapped on FDC and that, even if clearance is possible, years of treatment will be required.
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