ArticleProceedings of the National Academy of Sciences of the United States of America1999
How many mutations does it take to make a tumor?
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Durable complete clinical responses in a phase I/II trial using an autologous melanoma cell/dendritic cell vaccine.Cancer immunology, immunotherapy : CII · 2003Trial
- Mutations in tumor signaling, metastases, and synthetic lethality establish distinct patterns.PLoS computational biology · 2025Article
- Harnessing p53 for targeted cancer therapy: new advances and future directions.Transcription · 2025Review
- Cancer research and the mainstream of biology.Frontiers in cell and developmental biology · 2025Review
- Co-occurring Mutations in Different Genes Can Fuel Oncogenic Signaling and Serve as Metastatic Tumor Markers.bioRxiv : the preprint server for biology · 2024Article
- Tumor-Derived Antigenic Peptides as Potential Cancer Vaccines.International journal of molecular sciences · 2024Review
- Cancer and Autism: How PTEN Mutations Degrade Function at the Membrane and Isoform Expression in the Human Brain.Journal of molecular biology · 2023Article
- Editorial: Reshaping the diagnostic process in oncology: science versus technology.Frontiers in oncology · 2023Article
- Paradoxical Behavior of Oncogenes Undermines the Somatic Mutation Theory.Biomolecules · 2022Article
- Cancer prevention and screening: the next step in the era of precision medicine.NPJ precision oncology · 2019Review
- Methylation kinetics and CpG-island methylator phenotype status in colorectal cancer cell lines.Biology direct · 2013Article
- AMPKα2 Suppresses Murine Embryonic Fibroblast Transformation and Tumorigenesis.Genes & cancer · 2012Article
- Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells.Oncotarget · 2011Article
- Cancer immunotherapy by immunosuppression.Theoretical biology & medical modelling · 2010Article
- Cross-priming in health and disease.Nature reviews. Immunology · 2010Review
- Article
- Carcinogens induce genome-wide loss of heterozygosity in normal stem cells without persistent chromosomal instability.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Crypt dynamics and colorectal cancer: advances in mathematical modelling.Cell proliferation · 2006Article
- Anti-apoptotic proteins induce non-random genetic alterations that result in selecting breast cancer metastatic cells.Clinical & experimental metastasis · 2005Article
- Clement Richard Boland, Jr., MD: a conversation with the editor. Interview by William Clifford Roberts.Proceedings (Baylor University. Medical Center) · 2004Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
PubMed holds no abstract for this paper.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.