ArticleMolecular and cellular biology2000
Extracellular matrix-associated protein Sc1 is not essential for mouse development.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- Alpha-neurexins in health and disease.Frontiers in molecular neuroscience · 2025Review
- Matricellular Protein SPARCL1 Regulates Blood Vessel Integrity and Antagonizes Inflammatory Bowel Disease.Inflammatory bowel diseases · 2021Article
- Divergent Expression ofFrontiers in genetics · 2021Article
- Article
- Evolution of dental tissue mineralization: an analysis of the jawed vertebrate SPARC and SPARC-L families.BMC evolutionary biology · 2018Article
- Matricellular protein SPARCL1 regulates tumor microenvironment-dependent endothelial cell heterogeneity in colorectal carcinoma.The Journal of clinical investigation · 2016Article
- Mechanisms of otoconia and otolith development.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Review
- A dynamic history of gene duplications and losses characterizes the evolution of the SPARC family in eumetazoans.Proceedings. Biological sciences · 2013Article
- Effect of hevin deletion in mice and characterization in trabecular meshwork.Investigative ophthalmology & visual science · 2011Article
- Colon cancer stem cells: implications in carcinogenesis.Frontiers in bioscience (Landmark edition) · 2011Review
- Expression, functional, and structural analysis of proteins critical for otoconia development.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
- The role of astrocyte-secreted matricellular proteins in central nervous system development and function.Journal of cell communication and signaling · 2009Article
- Localization of the extracellular matrix protein SC1 coincides with synaptogenesis during rat postnatal development.Neurochemical research · 2008Article
- Article
- Localization of the extracellular matrix protein SC1 to synapses in the adult rat brain.Neurochemical research · 2007Article
- Microscale analysis of proteins in inner ear tissues and fluids with emphasis on endolymphatic sac, otoconia, and organ of Corti.Electrophoresis · 2006Article
- Matricellular homologs in the foreign body response: hevin suppresses inflammation, but hevin and SPARC together diminish angiogenesis.The American journal of pathology · 2005Article
- Intercellular adhesion molecules (ICAMs) and spermatogenesis.Human reproduction updateReview
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Sc1 is an extracellular matrix-associated protein whose function is unknown. During early embryonic development, Sc1 is widely expressed, and from embryonic day 12 (E12), Sc1 is expressed primarily in the developing nervous system. This switch in Sc1 expression at E12 suggests an importance for nervous-system development. To gain insight into Sc1 function, we used gene targeting to inactivate mouse Sc1. The Sc1-null mice showed no obvious deficits in any organs. These mice were born at the expected ratios, were fertile, and had no obvious histological abnormalities, and their long-term survival did not differ from littermate controls. Therefore, the function of Sc1 during development is not critical or, in its absence, is subserved by another protein.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.