ArticleMolecular and cellular biology2000
A novel subunit of yeast RNA polymerase III interacts with the TFIIB-related domain of TFIIIB70.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 73 citations in OpenAlex.
- Mutational and biophysical analyses reveal a TFIIIC binding region in the TFIIF-related Rpc53 subunit of RNA polymerase III.The Journal of biological chemistry · 2023Article
- Transcribing RNA polymerase III observed by electron cryomicroscopy.The FEBS journal · 2016Review
- Automated structure modeling of large protein assemblies using crosslinks as distance restraints.Nature methods · 2016Article
- Article
- Mapping the protein interaction network for TFIIB-related factor Brf1 in the RNA polymerase III preinitiation complex.Molecular and cellular biology · 2014Article
- Comparative overview of RNA polymerase II and III transcription cycles, with focus on RNA polymerase III termination and reinitiation.Transcription · 2014Review
- Role of CGRP-receptor component protein (RCP) in CLR/RAMP function.Current protein & peptide science · 2013Review
- Maf1-mediated repression of RNA polymerase III transcription inhibits tRNA degradation via RTD pathway.RNA (New York, N.Y.) · 2012Article
- Crystal structure of the C17/25 subcomplex from Schizosaccharomyces pombe RNA polymerase III.Protein science : a publication of the Protein Society · 2011Article
- Structure-function analysis of hRPC62 provides insights into RNA polymerase III transcription initiation.Nature structural & molecular biology · 2011Article
- Conformational flexibility of RNA polymerase III during transcriptional elongation.The EMBO journal · 2010Article
- Recruitment of RNA polymerase III in vivo.Nucleic acids research · 2008Article
- RNA polymerase transcription machinery in trypanosomes.Eukaryotic cell · 2008Article
- Maf1 is involved in coupling carbon metabolism to RNA polymerase III transcription.Molecular and cellular biology · 2007Article
- Interactions of Brf1 peptides with the tetratricopeptide repeat-containing subunit of TFIIIC inhibit and promote preinitiation complex assembly.Molecular and cellular biology · 2006Article
- Ancient origin, functional conservation and fast evolution of DNA-dependent RNA polymerase III.Nucleic acids research · 2006Article
- Structure-function analysis of the human TFIIB-related factor II protein reveals an essential role for the C-terminal domain in RNA polymerase III transcription.Molecular and cellular biology · 2005Article
- Reconfiguring the connectivity of a multiprotein complex: fusions of yeast TATA-binding protein with Brf1, and the function of transcription factor IIIB.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Domainal organization of the lower eukaryotic homologs of the yeast RNA polymerase II core subunit Rpb7 reflects functional conservation.Nucleic acids research · 2004Article
- Genome-wide location of yeast RNA polymerase III transcription machinery.The EMBO journal · 2003Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is limited information on how eukaryotic RNA polymerases (Pol) recognize their cognate preinitiation complex. We have characterized a polypeptide copurifying with yeast Pol III. This protein, C17, was found to be homologous to a mammalian protein described as a hormone receptor. Deletion of the corresponding gene, RPC17, was lethal and its regulated extinction caused a selective defect in transcription of class III genes in vivo. Two-hybrid and coimmunoprecipitation experiments indicated that C17 interacts with two Pol III subunits, one of which, C31, is important for the initiation reaction. C17 also interacted with TFIIIB70, the TFIIB-related component of TFIIIB. The interaction domain was found to be in the N-terminal, TFIIB-like half of TFIIIB70, downstream of the zinc ribbon and first imperfect repeat. Although Pol II similarly interacts with TFIIB, it is notable that C17 has no similarity to any Pol II subunit. The data indicate that C17 is a novel specific subunit of Pol III which participates together with C34 in the recruitment of Pol III by the preinitiation complex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.