ArticleMolecular and cellular biology2000
CLN1 and its repression by Xbp1 are important for efficient sporulation in budding yeast.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 50 citations in OpenAlex.
- Outcrossing inEcology and evolution · 2024Article
- Molecular background of HAC1-driven improvement in the secretion of recombinant protein inBiotechnology reports (Amsterdam, Netherlands) · 2023Article
- Functional characterization and comparative analysis of gene repression-mediating domains interacting with yeast pleiotropic corepressors Sin3, Cyc8 and Tup1.Current genetics · 2023Article
- Distinct requirements for the COMPASS core subunits Set1, Swd1, and Swd3 during meiosis in the budding yeast Saccharomyces cerevisiae.G3 (Bethesda, Md.) · 2021Article
- An APSES Transcription Factor Xbp1 Is Required for Sclerotial Development, Appressoria Formation, and Pathogenicity inFrontiers in microbiology · 2021Article
- Ascaroside Pheromones: Chemical Biology and Pleiotropic Neuronal Functions.International journal of molecular sciences · 2019Review
- Characterization of the APSES-family transcriptional regulators of Histoplasma capsulatum.FEMS yeast research · 2018Article
- Similar environments but diverse fates: Responses of budding yeast to nutrient deprivation.Microbial cell (Graz, Austria) · 2016Article
- A Genetic Screen for Saccharomyces cerevisiae Mutants That Fail to Enter Quiescence.G3 (Bethesda, Md.) · 2015Article
- Quantitative analysis of triple-mutant genetic interactions.Nature protocols · 2014Article
- Xbp1 directs global repression of budding yeast transcription during the transition to quiescence and is important for the longevity and reversibility of the quiescent state.PLoS genetics · 2013Article
- Systematic triple-mutant analysis uncovers functional connectivity between pathways involved in chromosome regulation.Cell reports · 2013Article
- Aneuploid yeast strains exhibit defects in cell growth and passage through START.Molecular biology of the cell · 2013Article
- Gis1 and Rph1 regulate glycerol and acetate metabolism in glucose depleted yeast cells.PloS one · 2012Article
- Regulation of entry into gametogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Review
- Xbp1-mediated histone H4 deacetylation contributes to DNA double-strand break repair in yeast.Cell research · 2011Article
- Low oxygen levels as a trigger for enhancement of respiratory metabolism in Saccharomyces cerevisiae.BMC genomics · 2009Article
- Sexual partners for the stressed: facultative outcrossing in the self-fertilizing nematode Caenorhabditis elegans.Evolution; international journal of organic evolution · 2009Article
- Transcriptional regulation of Saccharomyces cerevisiae CYS3 encoding cystathionine gamma-lyase.Current genetics · 2008Article
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2 authors at 1 institution in 2 countries.
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Abstract
Xbp1, a transcriptional repressor of Saccharomyces cerevisiae with homology to Swi4 and Mbp1, is induced by stress and starvation during the mitotic cycle. It is also induced late in the meiotic cycle. Using RNA differential display, we find that genes encoding three cyclins (CLN1, CLN3, and CLB2), CYS3, and SMF2 are downregulated when Xbp1 is overexpressed and that Xbp1 can bind to sequences in their promoters. During meiosis, XBP1 is highly induced and its mRNA appears at the same time as DIT1 mRNA, but its expression remains high for up to 24 h. As such, it represents a new class of meiosis-specific genes. Xbp1-deficient cells are capable of forming viable gametes, although ascus formation is delayed by several hours. Furthermore, Xbp1 target genes are normally repressed late in meiosis, and loss of XBP1 results in their derepression. Interestingly, we find that a deletion of CLN1 also reduces the efficiency of sporulation and delays the meiotic program but that sporulation in a Deltacln1 Deltaxbp1 strain is not further delayed. Thus, CLN1 may be Xbp1's primary target in meiotic cells. We hypothesize that CLN1 plays a role early in the meiotic program but must be repressed, by Xbp1, at later stages to promote efficient sporulation.
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Registered trials
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