ArticleJournal of molecular biology1999
RNA sequence and secondary structural determinants in a minimal viral promoter that directs replicase recognition and initiation of genomic plus-strand RNA synthesis.
Article in Journal of molecular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- Review
- An examination of the electrostatic interactions between the N-terminal tail of the Brome Mosaic Virus coat protein and encapsidated RNAs.Journal of molecular biology · 2012Article
- RNA synthesis by the brome mosaic virus RNA-dependent RNA polymerase in human cells reveals requirements for de novo initiation and protein-protein interaction.Journal of virology · 2012Article
- Small noncoding RNA modulates Japanese encephalitis virus replication and translation in trans.Virology journal · 2011Article
- Depurination within the intergenic region of Brome mosaic virus RNA3 inhibits viral replication in vitro and in vivo.Nucleic acids research · 2008Article
- In vitro synthesis of minus-strand RNA by an isolated cereal yellow dwarf virus RNA-dependent RNA polymerase requires VPg and a stem-loop structure at the 3' end of the virus RNA.Journal of virology · 2006Article
- Interaction between Brome mosaic virus proteins and RNAs: effects on RNA replication, protein expression, and RNA stability.Journal of virology · 2005Article
- Mutual interference between genomic RNA replication and subgenomic mRNA transcription in brome mosaic virus.Journal of virology · 2005Article
- Replicase-binding sites on plus- and minus-strand brome mosaic virus RNAs and their roles in RNA replication in plant cells.Journal of virology · 2004Article
- Repression and derepression of minus-strand synthesis in a plus-strand RNA virus replicon.Journal of virology · 2004Article
- Template sequence near the initiation nucleotide can modulate brome mosaic virus RNA accumulation in plant protoplasts.Journal of virology · 2004Article
- Brome mosaic virus RNA syntheses in vitro and in barley protoplasts.Journal of virology · 2003Article
- An alternate pathway for recruiting template RNA to the brome mosaic virus RNA replication complex.Journal of virology · 2003Article
- Mechanism of de novo initiation by the hepatitis C virus RNA-dependent RNA polymerase: role of divalent metals.Journal of virology · 2002Article
- Requirements for de novo initiation of RNA synthesis by recombinant flaviviral RNA-dependent RNA polymerases.Journal of virology · 2002Article
- A mutant viral RNA promoter with an altered conformation retains efficient recognition by a viral RNA replicase through a solution-exposed adenine.RNA (New York, N.Y.) · 2001Article
- Completion of RNA synthesis by viral RNA replicases.Nucleic acids research · 2001Article
- Template requirements for RNA synthesis by a recombinant hepatitis C virus RNA-dependent RNA polymerase.Journal of virology · 2000Article
- Efficient and specific initiation of subgenomic RNA synthesis by cucumber mosaic virus replicase in vitro requires an upstream RNA stem-loop.Journal of virology · 2000Article
- Template nucleotide moieties required for de novo initiation of RNA synthesis by a recombinant viral RNA-dependent RNA polymerase.Journal of virology · 2000Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Viral RNA replication provides a useful system to study the structure and function of RNAs and the mechanism of RNA synthesis from RNA templates. Previously we demonstrated that a 27 nt RNA from brome mosaic virus (BMV) can direct correct initiation of genomic plus-strand RNA synthesis by the BMV replicase. In this study, using biochemical, nuclear magnetic resonance, and thermodynamic analyses, we determined that the secondary structure of this 27 nt RNA can be significantly altered and retain the ability to direct RNA synthesis. In contrast, we find that position-specific changes in the RNA sequence will affect replicase recognition, modulate the polymerization process, and contribute to the differential accumulation of viral RNAs. These functional results are in agreement with the phylogenetic analysis of BMV and related viral sequences and suggest that a similar mechanism of RNA synthesis takes place for members of the alphavirus superfamily.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.