ArticleTransplantation1999
Peritransplant tolerance induction in macaques: early events reflecting the unique synergy between immunotoxin and deoxyspergualin.
Article in Transplantation, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 136 citations in OpenAlex.
- Treatment of active lupus nephritis with the novel immunosuppressant 15-deoxyspergualin: an open-label dose escalation study.Arthritis research & therapy · 2011Trial
- Lymphocyte Activation Markers in Pediatric Kidney Transplant Recipients.International journal of biomedical science : IJBS · 2015Article
- Current state of type 1 diabetes immunotherapy: incremental advances, huge leaps, or more of the same?Clinical & developmental immunology · 2011Review
- Induction of tolerance in clinical kidney transplantation.Clinical transplantation · 2010Review
- Induction of T regulatory cells attenuates idiopathic nephrotic syndrome.Journal of the American Society of Nephrology : JASN · 2009Article
- Adoptive immunotherapy against allogeneic kidney grafts in dogs with stable hematopoietic trichimerism.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2008Article
- Regulatory T cells: present facts and future hopes.Medical microbiology and immunology · 2006Review
- Induction of transplantation tolerance in non-human primate preclinical models.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2005Review
- Prolongation of liver allograft survival by dendritic cells modified with NF-kappaB decoy oligodeoxynucleotides.World journal of gastroenterology · 2004Article
- Dendritic cells, T cell tolerance and therapy of adverse immune reactions.Clinical and experimental immunology · 2003Review
- The complementary roles of deletion and regulation in transplantation tolerance.Nature reviews. Immunology · 2003Review
- Coxsackievirus-adenovirus receptor genetically fused to anti-human CD40 scFv enhances adenoviral transduction of dendritic cells.Gene therapy · 2002Article
- Islet transplantation in the twenty-first century.Immunologic research · 2002Review
- STEALTH in transplantation tolerance.Immunologic research · 2002Review
- Immunosuppressive drugs in paediatric liver transplantation.Paediatric drugs · 2001Review
- Donor and recipient leukocytes in organ allografts of recipients with variable donor-specific tolerance: with particular reference to chronic rejection.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2000Article
Corrections and comments
- Retraction · 2008-08-15Falsification/Fabrication of Data · Investigation by Company/Institution · Investigation by ORI · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author · · Juan L Contreras has NIH finding of misconduct: https://grants.nih.gov/grants/guide/notice-files/NOT-OD-09-119.html; Judith M Thomas has NIH finding of misconduct https://ori.hhs.gov/content/case-summary-thomas-judith-m
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- Retracted
Authors and funding
14 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundDay of transplant T cell depletion with anti-CD3 immunotoxin or F(Ab)2 immunotoxin induces stable tolerance to renal allografts in rhesus monkeys given 15-deoxyspergualin (DSG), a NF-kappaB inhibitor that suppresses proinflammatory cytokine (PC) production. Because PC and NF-kappaB are involved in dendritic cell (DC) maturation, we asked if impaired DC maturation and Th2-type cytokine deviation might be related to the synergistic effect of DSG in this novel model.
methodsImmunosuppression was initiated 4 hr before transplanting a major histocompatibility complex mismatched renal allograft. Some groups received a supplemental 5-day course of cyclosporine A or DSG or a 15-day course of DSG. Peripheral lymph nodes were sequentially examined for presence of mature DC. In vitro effects of DSG on PC-induced maturation of DC were also examined.
resultsAllografts survived without rejection in 87% of recipients given immunotoxin or F(Ab)2 immunotoxin with DSG x 15 days, in 50% with DSG x 5 days, and 0% with cyclosporine A. The longest DSG survivors are >1000 days with normal graft function and tolerance validated, including acceptance of challenge second donor kidneys without treatment. DSG-treated recipients were unique in developing polarized Th2-type plasma cytokines. In DSG recipients, mature DC were significantly reduced in day +5 lymph node biopsies, with complete repopulation by 30 days. In vitro studies verified an inhibitory effect of DSG on DC maturation.
conclusionsThe study suggests DSG arrests DC maturation. The unusual synergy of immunotoxin and DSG apparently involves coincidental reduction in lymph node T cell mass and mature DC, a transient circumstance favoring development of stable tolerance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.