ReviewInternational journal of experimental pathology1999
New vessels, new approaches: angiogenesis as a therapeutic target in musculoskeletal disorders.
Review in International journal of experimental pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 57 citations in OpenAlex.
- Efficacy of wIRA in the treatment of sacroiliitis in male patients with ankylosing spondylitis and its effect on serum VEGF levels.Journal of orthopaedic surgery and research · 2019Trial
- Serum VEGF and b-FGF profiles after tension-free or conventional hernioplasty.Langenbeck's archives of surgery · 2005Trial
- Comparison of growth factor concentrations in platelet-rich fibrin biomaterial in different systemic diseases.Clinical oral investigations · 2025Article
- Review
- Emerging Targets for the Treatment of Osteoarthritis: New Investigational Methods to Identify Neo-Vessels as Possible Targets for Embolization.Diagnostics (Basel, Switzerland) · 2022Review
- Bone Marrow Aspirate Concentrate-Enhanced Marrow Stimulation of Chondral Defects.Stem cells international · 2017Review
- Angiogenesis Dysregulation in Psoriatic Arthritis: Molecular Mechanisms.BioMed research international · 2017Review
- Macrophages and angiogenesis in rheumatic diseases.Vascular cell · 2013Article
- Atherosclerosis and endothelial dysfunction in patients with ankylosing spondylitis.Rheumatology international · 2010Review
- Vascular endothelial growth factor in children with cyanotic and acyanotic and congenital heart disease.Archives of medical science : AMS · 2010Article
- Human immunodeficiency virus vector-mediated intra-articular expression of angiostatin inhibits progression of collagen-induced arthritis in mice.Rheumatology international · 2005Article
- High serum vascular endothelial growth factor correlates with disease activity of spondylarthropathies.Clinical and experimental immunology · 2003Article
- The angiogenesis inhibitor protease-activated kringles 1-5 reduces the severity of murine collagen-induced arthritis.Arthritis research & therapy · 2003Article
- Angiogenesis in the female reproductive organs: pathological implications.International journal of experimental pathology · 2002Review
- Angiogenesis in rheumatoid arthritis.Arthritis research · 2002Review
- Ultrastructural response of pulmonary intravascular macrophages to exogenous oestrogen in the bovine lung: translocation of the surface-coat and enhanced cell membrane plasticity and angiogenesis.Journal of anatomy · 2001Article
- Does a pro-angiogenic state exist in the bone-implant interface of aseptically loosened joint prosthesis?Journal of materials science. Materials in medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Musculoskeletal disorders such as rheumatoid arthritis (RA) and osteoarthritis are a common cause of pain and disability. The vasculature is an important component of the musculoskeletal system, and vascularization is a key event in the development of normal cartilage and bone. By promoting the delivery of nutrients, oxygen and cells, blood vessels help maintain the structural and functional integrity of joints and soft tissue and may facilitate tissue repair and healing. The identification of pro-angiogenic mediators such as vascular endothelial growth factor (VEGF) has led to the development of antiangiogenic therapies for the treatment of neoplastic diseases. The important role of angiogenesis, and especially VEGF, in the pathogenesis of joint disorders such as RA suggests that antiangiogenic therapy may be a useful adjunct to existing approaches in RA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.