Trial reportBritish journal of clinical pharmacology2000
Auditory and electroencephalographic effects of midazolam and alpha-hydroxy-midazolam in healthy subjects.
Trial report in British journal of clinical pharmacology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 54 citations in OpenAlex.
- Dextromethorphan Versus Dextrorphan: A Quantitative Comparison of Antitussive Potency Following Separate Administration of Metabolite.Journal of clinical pharmacology · 2025Trial
- Quantification of the Time Course of CYP3A Inhibition, Activation, and Induction Using a Population Pharmacokinetic Model of Microdosed Midazolam Continuous Infusion.Clinical pharmacokinetics · 2022Trial
- Electrophysiological effects of psilocybin co-administered with midazolam.Translational psychiatry · 2026Article
- Comparison of electroencephalogram waveforms in older patients with/without dementia after administration of midazolam: a prospective, observational comparative study.Journal of dental anesthesia and pain medicine · 2026Article
- Resting State EEG Characteristics During Sedation With Midazolam or Propofol in Older Subjects.Clinical EEG and neuroscience · 2019Article
- Identification of a Core Amino Acid Motif within the α Subunit of GABACell reports · 2019Article
- Differential depression of neuronal network activity by midazolam and its main metabolite 1-hydroxymidazolam in cultured neocortical slices.Scientific reports · 2017Article
- Clinical neurophysiology of hepatic encephalopathy.Journal of clinical and experimental hepatology · 2015Review
- "I am resting but rest less well with you." The moderating effect of anxious attachment style on alpha power during EEG resting state in a social context.Frontiers in human neuroscience · 2014Article
- Lack of effect of subject posture on intravenous midazolam clearance: implications for hepatic cytochrome P450 3A phenotyping.British journal of clinical pharmacology · 2009Article
- Block-dependent sedation during epidural anaesthesia is associated with delayed brainstem conduction.British journal of anaesthesia · 2004Article
- Comparative tolerability of sedative agents in head-injured adults.Drug safety · 2004Review
- Phenotyping CYP3A using midazolam in cancer and noncancer Asian patients.British journal of clinical pharmacology · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsWhereas cortical EEG effects of benzodiazepines are well characterized, information about benzodiazepine effects in other areas of the central nervous system is sparse. This study investigated the action of midazolam and its active metabolite alpha-hydroxy-midazolam on different parts of the auditory pathway in six healthy volunteers in a randomized, double-blind, three-way cross-over study.
methodsAcoustically evoked short (SLP) and middle (MLP) latency potentials, transitory evoked otoacoustic emissions (TEOAE), and EEG power spectra were analysed after short i. v. injections of placebo, or 0.15 mg kg-1 midazolam, or alpha-hydroxy-midazolam, respectively.
resultsAll subjects fell asleep during the 4 min infusion of active drug. SLP showed a significant transient increase of Jewett wave V 10 min after injection for midazolam and alpha-hydroxy-midazolam while the latency of wave I was unchanged. Both benzodiazepines induced a marked and long-lasting MLP amplitude decrease for 240 min with slow recovery over the following 360 min. No changes of TEOAE were observed. In agreement with earlier reports, increases in EEG beta activity and decreases in alpha activity were observed after administration of either drug.
conclusionsSystemically administered benzodiazepines modulate the auditory pathway above the level of the cochlea. While SLP changes were closely associated with sedation and high plasma benzodiazepine concentrations, MLP effects persisted for hours after sedation even at low benzodiazepine plasma levels. Evoked potentials may therefore be more sensitive than EEG as a tool to monitor benzodiazepine effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.