ArticleNucleic acids research2000
Myc induces the nucleolin and BN51 genes: possible implications in ribosome biogenesis.
Article in Nucleic acids research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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Who cites it
67 citing papers in PubMed, 123 citations in OpenAlex.
- Hypoxia inducible factors inhibit respiratory syncytial virus infection by modulation of nucleolin expression.iScience · 2024Article
- Intracellular Delivery of an Antibody-Like Molecule Capable of Inhibiting c-Myc.Doklady. Biochemistry and biophysics · 2023Article
- N-myc-Mediated Translation Control Is a Therapeutic Vulnerability in Medulloblastoma.Cancer research · 2023Article
- Review
- Long non-coding RNAs involved in cancer metabolic reprogramming.Cellular and molecular life sciences : CMLS · 2019Review
- Oral Delivery of miRNA With Lipidic Aminoglycoside Derivatives in the Breastfed Rat.Frontiers in physiology · 2019Article
- Aberrant expression of CITED2 promotes prostate cancer metastasis by activating the nucleolin-AKT pathway.Nature communications · 2018Article
- SET mediates TCE-induced liver cell apoptosis through dephosphorylation and upregulation of nucleolin.Oncotarget · 2017Article
- c-Myc is Required for BRAFTheranostics · 2017Article
- c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinoma.Oncotarget · 2016Article
- C23 promotes tumorigenesis via suppressing p53 activity.Oncotarget · 2016Article
- Regulation of nucleolin expression by miR-194, miR-206, and HuR.Molecular and cellular biochemistry · 2016Article
- Drosophila Myc: A master regulator of cellular performance.Biochimica et biophysica acta · 2015Review
- snoRNAs are a novel class of biologically relevant Myc targets.BMC biology · 2015Article
- Targeting tumor-initiating cells: eliminating anabolic cancer stem cells with inhibitors of protein synthesis or by mimicking caloric restriction.Oncotarget · 2015Article
- Pair-wise comparison analysis of differential expression of mRNAs in early and advanced stage primary colorectal adenocarcinomas.BMJ open · 2014Article
- The interaction of MYC with the trithorax protein ASH2L promotes gene transcription by regulating H3K27 modification.Nucleic acids research · 2014Article
- MYC regulation of cell growth through control of transcription by RNA polymerases I and III.Cold Spring Harbor perspectives in medicine · 2014Review
- Article
- Dual regulation of Myc by Abl.Oncogene · 2013Article
7 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The c-Myc oncoprotein and its dimerization partner Max bind the DNA core consensus sequence CACGTG (E-box) and activate gene transcription. However, the low levels of induction have hindered the identification of novel Myc target genes by differential screening techniques. Here, we describe a computer-based pre-selection of candidate Myc/Max target genes, based on two restrictive criteria: an extended E-box consensus sequence for Myc/Max binding and the occurrence of this sequence within a potential genomic CpG island. Candidate genes selected by these criteria were evaluated experimentally for their response to Myc. Two Myc target genes are characterized here in detail. These encode nucleolin, an abundant nucleolar protein, and BN51, a co-factor of RNA polymerase III. Myc activates transcription of both genes via E-boxes located in their first introns, as seen for several well-characterized Myc targets. For both genes, mutation of the E-boxes abolishes transcriptional activation by Myc as well as repression by Mad1. In addition, the BN51 promoter is selectively activated by Myc and not by USF, another E-box-binding factor. Both nucleolin and BN51 are implicated in the maturation of ribosomal RNAs, albeit in different ways. We propose that Myc, via regulation of these and probably many other transcriptional targets, may be an important regulator of ribosome biogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.