ArticleJournal of clinical pathology1999
Infrequent loss of heterozygosity of APC/MCC and DCC genes in gastric cancer showing DNA microsatellite instability.
Article in Journal of clinical pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 38 citations in OpenAlex.
- hsa-miR-29c and hsa-miR-135b differential expression as potential biomarker of gastric carcinogenesis.World journal of gastroenterology · 2016Article
- H. pylori infection is related to mitochondrial microsatellite instability in gastric carcinogenesis.Infectious agents and cancer · 2016Article
- Review
- Premalignant lesions in gastric cancer.Clinical journal of gastroenterology · 2010Article
- Microsatellite instability and loss of heterozygosity of tumor suppressor genes in Bosnian patients with sporadic colorectal cancer.Bosnian journal of basic medical sciences · 2008Article
- Tumor suppresser gene p53 expression in premalignant lesions and gastric carcinoma - prognostic value.Bosnian journal of basic medical sciences · 2007Article
- Microsatellite instability in gastric cancer and pre-cancerous lesions.World journal of gastroenterology · 2005Article
- Mitochondrial microsatellite instability in gastric cancer and its precancerous lesions.World journal of gastroenterology · 2004Article
- Expression of pituitary tumor transforming gene in human gastric carcinoma.World journal of gastroenterology · 2004Article
- Mutation and methylation of hMLH1 in gastric carcinomas with microsatellite instability.World journal of gastroenterology · 2003Article
- Telomere erosion is independent of microsatellite instability but related to loss of heterozygosity in gastric cancer.World journal of gastroenterology · 2001Article
- Altered mucin expression in the gastrointestinal tract: a review.Journal of cellular and molecular medicineReview
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the role of DNA microsatellite instability (MSI) in gastric carcinogenesis by studying associations between MSI status, clinicopathological features, and loss of genetic loci.
methodsSix microsatellite loci and loss of heterozygosity at APC, DCC, and MCC were analysed by polymerase chain reaction based methods in 53 cases of advanced gastric cancer.
resultsMSI was observed in 32.1% of gastric carcinomas (17/53) and 20% of foci of intestinal metaplasia (3/15). Seven gastric carcinomas (13.7%) were MSI-high (MSI-H) (three loci or more) and 10 (18.9%) were MSI-low (MSI-L) (one or two loci). The frequency of MSI-H was higher in intestinal (25.0%) than in diffuse carcinomas (3.7%) (p < 0.05). None of the MSI-H tumours showed loss of heterozygosity at APC, MCC, or DCC loci.
conclusionsMSI may have an important and early role in a subset of gastric cancers, particularly the intestinal type. The MSI-H subset of gastric cancer has features in common with its colorectal counterpart, whereas MSI-L and microsatellite stable cancers appear to develop through the loss of heterozygosity pathway.
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