ArticleBritish journal of cancer1999
Reduction in membranous expression of beta-catenin and increased cytoplasmic E-cadherin expression predict poor survival in gastric cancer.
Article in British journal of cancer, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Pooled it
- Abnormal β-catenin immunohistochemical expression as a prognostic factor in gastric cancer: a meta-analysis.World journal of gastroenterology · 2014Pooled it
- Expression patterns of seven key genes, including β-catenin, Notch1, GATA6, CDX2, miR-34a, miR-181a and miR-93 in gastric cancer.Scientific reports · 2020Trial
- Article
- Article
- Predictive value of E-cadherin and EpCAM for detection of metastatic lymph node in early gastric cancer.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2020Article
- Altered expression of epithelial-to-mesenchymal transition proteins in extraprostatic prostate cancer.Oncotarget · 2016Article
- Nomogram Incorporating CD44v6 and Clinicopathological Factors to Predict Lymph Node Metastasis for Early Gastric Cancer.PloS one · 2016Article
- The prognostic value of β-catenin and LEF-1 expression in patients with operable gastric carcinoma.American journal of translational research · 2016Article
- Loss of vinculin and membrane-bound β-catenin promotes metastasis and predicts poor prognosis in colorectal cancer.Molecular cancer · 2014Article
- Epistemology of the origin of cancer: a new paradigm.BMC cancer · 2014Article
- Helicobacter pylori impedes acid-induced tightening of gastric epithelial junctions.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- A novel CDH1 germline missense mutation in a sporadic gastric cancer patient in north-east of Italy.Clinical and experimental medicine · 2013Article
- Understanding the role of keratins 8 and 18 in neoplastic potential of breast cancer derived cell lines.PloS one · 2013Article
- Clinicopathological significance of lymphatic vessel density marked by D2-40 and E-cadherin expression in non-small-cell lung cancer.Medical oncology (Northwood, London, England) · 2012Article
- RNA-binding protein quaking, a critical regulator of colon epithelial differentiation and a suppressor of colon cancer.Gastroenterology · 2010Article
- Cadherin-catenin adhesion system and mucin expression: a comparison between young and older patients with gastric carcinoma.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2008Article
- Effects of Helicobacter pylori on the cadherin-catenin complex.Journal of clinical pathology · 2006Article
- Helicobacter pylori infection targets adherens junction regulatory proteins and results in increased rates of migration in human gastric epithelial cells.Infection and immunity · 2004Article
- Allelic imbalance of 8p indicates poor survival in gastric cancer.The Journal of molecular diagnostics : JMD · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
beta-catenin, a component of the E-cadherin-catenin cell adhesion complex, also plays a separate intracellular signalling role, interacting with APC protein. Intracellular accumulation of beta-catenin is common in colorectal neoplasia. beta-catenin abnormalities are associated with poor survival in gastric cancer, but previous studies do not differentiate between membrane-associated and intracellular beta-catenin. In this study we aimed to determine which type of expression abnormalities for E-cadherin, beta-catenin and alpha-catenin correlate with clinico-pathological features and survival in gastric cancer. Immunoperoxidase staining of paraffin-embedded sections from 40 gastric cancers was performed for E-cadherin, alpha- and beta-catenins using microwave unmasking and an avidin-biotin technique. Clinical data were obtained from case records and cancer registry records. Reduced membranous expression of beta-catenin occurred in 10/12 (83%) diffuse and 8/28 (29%) intestinal tumours (P= 0.0014), and was associated with poor differentiation (P= 0.0015) and short survival (P= 0.032), but not with age, sex, tumour size or nodal status. Nuclear expression of beta-catenin was uncommon; cytoplasmic expression was observed in 13/40 cases (33%) but did not correlate with histology, tumour grade or survival. Reduced E-cadherin membrane expression was associated with lymph node metastasis (P= 0.02). Neither E-cadherin or alpha-catenin expression correlated with survival. Reduced membranous expression of beta-catenin predicts poor prognosis in gastric cancer, whilst ectopic intracellular expression is relatively rare. The apparent differences in beta-catenin expression from those found in colon cancer merit further study.
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