Evidence map›Paper›PMID 10603420›Full record

ArticleInfection and immunity2000

Isolation of Bacteroides fragilis mutants with in vivo growth defects by using Tn4400', a modified Tn4400 transposition system, and a new screening method.

Y P Tang, M H Malamy

Abstract read
In one paragraph

Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Lessons from the model gut BacteroidalesJournal of bacteriology · 2025
    Review
  2. Article
  3. Article
  4. Article
  5. Gut SymbiontmBio · 2017
    Article
  6. Article
  7. Article
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  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Y P TangDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.
M H Malamy

Funding

GENETIC SYSTEMS TO STUDY VIRULENCE IN B FRAGILISR01AI019497 · NIAID · TUFTS UNIVERSITY BOSTON · PI MALAMY, MICHAEL H · 1985 to 2008
$2.6M
Genetic System to Study Virulence in BacteroidesR21AI019497 · NIAID · TUFTS UNIVERSITY BOSTON · PI MALAMY, MICHAEL H · 2003 to 2003
$390k
NIAID NIH HHS AI-19497NIAID NIH HHS R01 AI019497NIAID NIH HHS R21 AI019497
6 · The paper itself

Abstract

A modified version of the Bacteroides fragilis transposon Tn4400, designated Tn4400', enabling rapid isolation and analysis of B. fragilis mutants has been constructed. To identify potential virulence factors, Tn4400'-generated mutants were screened by a new method; this resulted in the isolation of 21 mutant strains with impaired growth characteristics on tissue culture monolayers but normal growth in rich medium anaerobically.

Indexed as

MutationAnimalsBacteroides fragilisCell LineChromosomes, BacterialCloning, MolecularDNA Transposable ElementsEscherichia coliGenetic TechniquesMutagenesis, InsertionalPlasmidsVirulenceDNA Transposable Elements

Identifiers

PMID10603420
PMCPMC97153

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.