ArticleInfection and immunity2000
Toxoplasma gondii infection induces gene expression and secretion of interleukin 1 (IL-1), IL-6, granulocyte-macrophage colony-stimulating factor, and intercellular adhesion molecule 1 by human retinal pigment epithelial cells.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 77 citations in OpenAlex.
- Comprehensive analysis of Toxoplasma gondii migration routes and tissue dissemination in the host.PLoS neglected tropical diseases · 2025Review
- Role ofFrontiers in ophthalmology · 2023Article
- LFA-1/ ICAM-1 promotes NK cell cytotoxicity associated with the pathogenesis of ocular toxoplasmosis in murine model.PLoS neglected tropical diseases · 2022Article
- Article
- Comparative Proteomics Analysis for Elucidating the Interaction Between Host Cells andFrontiers in cellular and infection microbiology · 2021Article
- Human immunity to Toxoplasma gondii.PLoS pathogens · 2019Review
- Expression and regulation of alarmin cytokine IL-1α in human retinal pigment epithelial cells.Experimental eye research · 2018Article
- Article
- Production of IL-1β and Inflammasome with Up-Regulated Expressions of NOD-Like Receptor Related Genes inThe Korean journal of parasitology · 2016Article
- Besnoitia besnoiti infections activate primary bovine endothelial cells and promote PMN adhesion and NET formation under physiological flow condition.Parasitology research · 2016Article
- Experimental Models of Ocular Infection with Toxoplasma Gondii.European journal of microbiology & immunology · 2015Article
- Contribution of IL6 -174 G>C and IL1B +3954 C>T polymorphisms to congenital infection with Toxoplasma gondii.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Article
- Suitable in vitro culture of Eimeria bovis meront II stages in bovine colonic epithelial cells and parasite-induced upregulation of CXCL10 and GM-CSF gene transcription.Parasitology research · 2015Article
- Article
- Article
- Human innate immunity to Toxoplasma gondii is mediated by host caspase-1 and ASC and parasite GRA15.mBio · 2013Article
- Immune response and immunopathology during toxoplasmosis.Seminars in immunopathology · 2012Review
- Expression and functional roles of caspase-5 in inflammatory responses of human retinal pigment epithelial cells.Investigative ophthalmology & visual science · 2011Article
- Toxoplasma gondii down modulates cadherin expression in skeletal muscle cells inhibiting myogenesis.BMC microbiology · 2011Article
- Immune regulation in the retina.Immunologic research · 2010Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We have used human retinal pigment epithelial (HRPE) cultures to investigate the primary cellular responses of retinal resident cells to intracellular Toxoplasma gondii replication. At 4 days postinoculation, when all of the cells were infected, the secretion of interleukin 1beta (IL-1beta), IL-6, granulocyte-macrophage colony-stimulating factor (GM-CSF), and intercellular adhesion molecule 1 (ICAM-1) was augmented by 23-, 10-, 8-, and 5-fold, respectively, over the control. Northern and reverse transcriptase PCR analyses showed significant upregulation of steady-state levels of mRNA for IL-1beta, IL-6, GM-CSF, and ICAM-1. The secretion of these molecules by HRPE cells may play a critical immunoregulatory role in the pathophysiological processes associated with T. gondii-induced retinochoroiditis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.