ArticleInfection and immunity2000
Evaluation of Mycobacterium tuberculosis genes involved in resistance to killing by human macrophages.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
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- Trypanosoma cruzi Differentiates and Multiplies within Chimeric Parasitophorous Vacuoles in Macrophages Coinfected with Leishmania amazonensis.Infection and immunity · 2016Article
- Differential cellular recognition pattern to M. tuberculosis targets defined by IFN-γ and IL-17 production in blood from TB + patients from Honduras as compared to health care workers: TB and immune responses in patients from Honduras.BMC infectious diseases · 2013Article
- Article
- Theoretical studies on the interaction of biphenyl inhibitors with Mycobacterium tuberculosis protein tyrosine phosphatase MptpB.Journal of molecular modeling · 2012Article
- Pattern recognition and cellular immune responses to novel Mycobacterium tuberculosis-antigens in individuals from Belarus.BMC infectious diseases · 2012Article
- The genome of Mycobacterium africanum West African 2 reveals a lineage-specific locus and genome erosion common to the M. tuberculosis complex.PLoS neglected tropical diseases · 2012Article
- Rapid identification and detection of intracellular survival testing of mycobacterium smegmatis mc²155 that contains eis gene from mycobacterium tuberculosis by flow cytometry.Current microbiology · 2011Article
- Glutamine synthetase sequence evolution in the mycobacteria and their use as molecular markers for Actinobacteria speciation.BMC evolutionary biology · 2009Article
- Molecular characterization of clinical isolates of Mycobacterium tuberculosis and their association with phenotypic virulence in human macrophages.Clinical and vaccine immunology : CVI · 2007Article
- Mycobacterium marinum strains can be divided into two distinct types based on genetic diversity and virulence.Infection and immunity · 2004Article
- Identification of Mycobacterium tuberculosis counterimmune (cim) mutants in immunodeficient mice by differential screening.Infection and immunity · 2004Article
- Methionine sulfoxide reductase A (MsrA) deficiency affects the survival of Mycobacterium smegmatis within macrophages.Journal of bacteriology · 2004Article
- Structure of Mycobacterium tuberculosis methionine sulfoxide reductase A in complex with protein-bound methionine.Journal of bacteriology · 2003Article
- Heterogeneity of RNA polymerase gene (rpoB) sequences of Mycobacterium gordonae clinical isolates identified with a DNA probe kit and by conventional methods.Journal of clinical microbiology · 2003Article
- Phospholipase region of Mycobacterium tuberculosis is a preferential locus for IS6110 transposition.Journal of clinical microbiology · 2001Article
- Identification of two Mycobacterium tuberculosis H37Rv ORFs involved in resistance to killing by human macrophages.BMC microbiology · 2001Article
- glnE is an essential gene in Mycobacterium tuberculosis.Journal of bacteriology · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A coinfection assay was developed to examine Mycobacterium tuberculosis genes suspected to be involved in resistance to killing by human macrophages. THP-1 macrophages were infected with a mixture of equal numbers of recombinant Mycobacterium smegmatis LR222 bacteria expressing an M. tuberculosis gene and wild-type M. smegmatis LR222 bacteria expressing the xylE gene. At various times after infection, the infected macrophages were lysed and the bacteria were plated. The resulting colonies were sprayed with catechol to determine the number of recombinant colonies and the number of xylE-expressing colonies. M. smegmatis bacteria expressing the M. tuberculosis glutamine synthetase A (glnA) gene or open reading frame Rv2962c or Rv2958c demonstrated significantly increased survival rates in THP-1 macrophages relative to those of xylE-expressing bacteria. M. smegmatis bacteria expressing M. tuberculosis genes for phospholipase C (plcA and plcB) or for high temperature requirement A (htrA) did not.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.