ArticleInfection and immunity2000
Resistance of transgenic mice expressing human group II phospholipase A2 to Escherichia coli infection.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 84 citations in OpenAlex.
- Secreted phospholipase A2 regulates intercellular communications by coordinating extracellular phospholipid metabolism.International immunology · 2025Review
- Article
- Old but New: Group IIA Phospholipase AMetabolites · 2022Review
- Gut commensal bacteria, Paneth cells and their relations to radiation enteropathy.World journal of stem cells · 2020Review
- Expression and Roles of Antimicrobial Peptides in Innate Defense of Airway Mucosa: Potential Implication in Cystic Fibrosis.Frontiers in immunology · 2020Review
- Antimalarial Activity of Human Group IIA Secreted Phospholipase AInfection and immunity · 2019Article
- Lipocalin 24p3 Induction in Colitis Adversely Affects Inflammation and Contributes to Mortality.Frontiers in immunology · 2019Article
- Impact of Paneth Cell Autophagy on Inflammatory Bowel Disease.Frontiers in immunology · 2018Review
- Article
- The Roles of the Secreted Phospholipase AAdvances in immunology · 2016Review
- A new era of secreted phospholipase A₂.Journal of lipid research · 2015Article
- In vitro anti-Plasmodium falciparum properties of the full set of human secreted phospholipases A2.Infection and immunity · 2015Article
- Secreted phospholipase A2 is increased in meconium-stained amniotic fluid of term gestations: potential implications for the genesis of meconium aspiration syndrome.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2014Article
- Partial deletion of chromosome 8 β-defensin cluster confers sperm dysfunction and infertility in male mice.PLoS genetics · 2013Article
- Aromatase inhibitors, estrogens and musculoskeletal pain: estrogen-dependent T-cell leukemia 1A (TCL1A) gene-mediated regulation of cytokine expression.Breast cancer research : BCR · 2012Article
- Biology of secretory phospholipase A2.Cardiovascular drugs and therapy · 2009Review
- Multiple roles of phospholipase A2 during lung infection and inflammation.Infection and immunity · 2008Review
- Role of secretory phospholipase a(2) in CNS inflammation: implications in traumatic spinal cord injury.CNS & neurological disorders drug targets · 2008Review
- Wall teichoic acid deficiency in Staphylococcus aureus confers selective resistance to mammalian group IIA phospholipase A(2) and human beta-defensin 3.Infection and immunity · 2008Article
- Lysis of human immunodeficiency virus type 1 by a specific secreted human phospholipase A2.Journal of virology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Group II phospholipase A2 (PLA2) is a newly recognized antibacterial acute-phase protein. Recently we observed that transgenic mice expressing group II PLA2 (PLA2(+) mice) were able to resist experimental Staphylococcus aureus infection by killing the bacteria, as indicated by improved survival and by the small numbers of live bacteria in their tissues (V. J. O. Laine, D. S. Grass, and T. J. Nevalainen, J. Immunol. 162:7402-7408, 1999). To establish the role of group II PLA2 in Escherichia coli infection, the host responses of PLA2(+) mice and their PLA2-deficient C57BL/6J littermates (PLA2(-) mice) were studied after intraperitoneal administration of E. coli. The levels of group II PLA2 in sera of PLA2(+) mice increased after the administration of E. coli, and the concentration of group II PLA2 correlated significantly with the catalytic activity of PLA2 in serum. PLA2(+) mice showed lower rates of mortality and less bacterial growth in peritoneal lavage fluid, blood, and spleen and liver tissues than PLA2(-) mice. Unlike the observations with staphylococcal infection, serum and peritoneal lavage fluid did not inhibit the growth of E. coli in vitro. The results indicate that expression of the group II PLA2 transgene improves the host defense of mice against E. coli infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.