ArticleInfection and immunity2000
Increased expression of periplasmic Cu,Zn superoxide dismutase enhances survival of Escherichia coli invasive strains within nonphagocytic cells.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 64 citations in OpenAlex.
- Superoxide dismutase VPA1514 in Vibrio parahaemolyticus protects against environmental stresses.PloS one · 2025Article
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- Improvement of sabinene tolerance ofBiotechnology for biofuels · 2020Article
- Identification and Molecular Characterization of Superoxide Dismutases Isolated From A Scuticociliate Parasite: Physiological Role in Oxidative Stress.Scientific reports · 2019Article
- Intelligent Metal-Phenolic Metallogels as Dressings for Infected Wounds.Scientific reports · 2019Article
- New role for the ibeA gene in H2O2 stress resistance of Escherichia coli.Journal of bacteriology · 2012Article
- Evolution of the metabolic and regulatory networks associated with oxygen availability in two phytopathogenic enterobacteria.BMC genomics · 2012Article
- Copper, Zinc-Superoxide Dismutase from Clinically Isolated Escherichia coli: Cloning, Analysis of sodC and Its Possible Role in Pathogenicity.Indian journal of microbiology · 2011Article
- Article
- Regulatory and structural properties differentiating the chromosomal and the bacteriophage-associated Escherichia coli O157:H7 Cu, Zn superoxide dismutases.BMC microbiology · 2008Article
- Regulatory and structural differences in the Cu,Zn-superoxide dismutases of Salmonella enterica and their significance for virulence.The Journal of biological chemistry · 2008Article
- Superoxide dismutase B gene (sodB)-deficient mutants of Francisella tularensis demonstrate hypersensitivity to oxidative stress and attenuated virulence.Journal of bacteriology · 2006Article
- Defenses against oxidative stress in Neisseria gonorrhoeae: a system tailored for a challenging environment.Microbiology and molecular biology reviews : MMBR · 2006Review
- Azurin of pathogenic Neisseria spp. is involved in defense against hydrogen peroxide and survival within cervical epithelial cells.Infection and immunity · 2005Article
- Investigation of oxidative stress defenses of Neisseria gonorrhoeae by using a human polymorphonuclear leukocyte survival assay.Infection and immunity · 2005Article
- Molecular characterization and quantitative analysis of superoxide dismutases in virulent and avirulent strains of Aeromonas salmonicida subsp. salmonicida.Journal of bacteriology · 2003Article
- Bacterial [Cu,Zn]-cofactored superoxide dismutase protects opsonized, encapsulated Neisseria meningitidis from phagocytosis by human monocytes/macrophages.Infection and immunity · 2003Article
- Inactivation of the Moraxella catarrhalis superoxide dismutase SodA induces constitutive expression of iron-repressible outer membrane proteins.Infection and immunity · 2002Article
- Lipid modification of the Cu,Zn superoxide dismutase from Mycobacterium tuberculosis.The Biochemical journal · 2001Article
- Interruption of the cydB locus in Brucella abortus attenuates intracellular survival and virulence in the mouse model of infection.Journal of bacteriology · 2001Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have studied the influence of periplasmic Cu,Zn superoxide dismutase on the intracellular survival of Escherichia coli strains able to invade epithelial cells by the expression of the inv gene from Yersinia pseudotuberculosis but unable to multiply intracellularly. Intracellular viability assays, confirmed by electron microscopy observations, showed that invasive strains of E. coli engineered to increase Cu,Zn superoxide dismutase production are much more resistant to intracellular killing than strains containing only the chromosomal sodC copy. However, we have found only a slight difference in survival within HeLa cells between a sodC-null mutant and its isogenic wild-type strain. Such a small difference in survival correlates with the very low expression of this enzyme in the wild-type strain. We have also observed that acid- and oxidative stress-sensitive E. coli HB101(pRI203) is more rapidly killed in epithelial cells than E. coli GC4468(pRI203). The high mortality of E. coli HB101(pRI203), independent of the acidification of the endosome, is abolished by the overexpression of sodC. Our data suggest that oxyradicals are involved in the mechanisms of bacterial killing within epithelial cells and that high-level production of periplasmic Cu,Zn superoxide dismutase provides bacteria with an effective protection against oxidative damage. We propose that Cu,Zn superoxide dismutase could offer an important selective advantage in survival within host cells to bacteria expressing high levels of this enzyme.
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