ArticleInfection and immunity2000
Characterization of PaxA and its operon: a cohemolytic RTX toxin determinant from pathogenic Pasteurella aerogenes.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 77 citations in OpenAlex.
- First detection of multidrug-resistant and toxigenic Pasteurella aerogenes in sow vaginal discharge: a novel threat to swine health in Thailand.Scientific reports · 2024Article
- Bacterial Contamination and Antimicrobial Resistance in Two-Spotted (Veterinary sciences · 2024Article
- Type 1 secretion necessitates a tight interplay between all domains of the ABC transporter.Scientific reports · 2024Article
- Heterologously secreted MbxA from Moraxella bovis induces a membrane blebbing response of the human host cell.Scientific reports · 2022Article
- Investigations on the substrate binding sites of hemolysin B, an ABC transporter, of a type 1 secretion system.Frontiers in microbiology · 2022Article
- Identity Determinants of the Translocation Signal for a Type 1 Secretion System.Frontiers in physiology · 2021Article
- Effects and interaction of dietary electrolyte balance and citric acid on the intestinal function of weaned piglets.Journal of animal science · 2020Article
- Hygienic quality, adulteration of pork and histamine production by Raoultella ornithinolytica in milkfish dumpling.Journal of food and drug analysis · 2016Article
- Experimental Identification of Small Non-Coding RNAs in the Model Marine Bacterium Ruegeria pomeroyi DSS-3.Frontiers in microbiology · 2016Article
- Determination of histamine in milkfish stick implicated in food-borne poisoning.Journal of food and drug analysis · 2016Article
- Degradation of histamine by Bacillus polymyxa isolated from salted fish products.Journal of food and drug analysis · 2015Article
- The histamine content of dried flying fish products in Taiwan and the isolation of halotolerant histamine-forming bacteria.Journal of food and drug analysis · 2015Article
- Cytotoxic and pathogenic properties of Klebsiella oxytoca isolated from laboratory animals.PloS one · 2014Article
- Acyltransferases in bacteria.Microbiology and molecular biology reviews : MMBR · 2013Review
- Ehrlichia chaffeensis tandem repeat proteins and Ank200 are type 1 secretion system substrates related to the repeats-in-toxin exoprotein family.Frontiers in cellular and infection microbiology · 2011Article
- RTX proteins: a highly diverse family secreted by a common mechanism.FEMS microbiology reviews · 2010Review
- In-depth analysis of exoproteomes from marine bacteria by shotgun liquid chromatography-tandem mass spectrometry: the Ruegeria pomeroyi DSS-3 case-study.Marine drugs · 2010Article
- Identification, cloning, and expression of the CAMP-like factor autotransporter gene (cfa) of Bartonella henselae.Infection and immunity · 2005Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pasteurella aerogenes is known as a commensal bacterium or as an opportunistic pathogen, as well as a primary pathogen found to be involved in abortion cases of humans, swine, and other mammals. Using broad-range DNA probes for bacterial RTX toxin genes, we cloned and subsequently sequenced a new operon named paxCABD encoding the RTX toxin PaxA in P. aerogenes. The pax operon is organized analogous to the classical RTX operons containing the activator gene paxC upstream of the structural toxin gene paxA, which is followed by the secretion protein genes paxB and paxD. The highest sequence similarity of paxA with known RTX toxin genes is found with apxIIIA (82%). PaxA is structurally similar to ApxIIIA and also shows functional analogy to ApxIIIA, since it shows cohemolytic activity with the sphingomyelinase of Staphylococcus aureus, known as the CAMP effect, but is devoid of direct hemolytic activity. In addition, it shows to some extent immunological cross-reactions with ApxIIIA. P. aerogenes isolated from various specimens showed that the pax operon was present in about one-third of the strains. All of the pax-positive strains were specifically related to swine abortion cases or septicemia of newborn piglets. These strains were also shown to produce the PaxA toxin as determined by the CAMP phenomenon, whereas none of the pax-negative strains did. This indicated that the PaxA toxin is involved in the pathogenic potential of P. aerogenes. The examined P. aerogenes isolates were phylogenetically analyzed by 16S rRNA gene (rrs) sequencing in order to confirm their species. Only a small heterogeneity (<0.5%) was observed between the rrs genes of the strains originating from geographically distant farms and isolated at different times.
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