ArticleOncogene1999
Expression of the SRF gene occurs through a Ras/Sp/SRF-mediated-mechanism in response to serum growth signals.
Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 43 citations in OpenAlex.
- Actomyosin and the MRTF-SRF pathway downregulate FGFR1 in mesenchymal stromal cells.Communications biology · 2020Article
- CRE and SRE mediate LPA-induced CCN1 transcription in mouse aortic smooth muscle cells.Canadian journal of physiology and pharmacology · 2017Article
- HOPX functions as a tumour suppressor in head and neck cancer.Scientific reports · 2016Article
- MiR-320a contributes to atherogenesis by augmenting multiple risk factors and down-regulating SRF.Journal of cellular and molecular medicine · 2015Article
- Smooth Muscle Cell Genome Browser: Enabling the Identification of Novel Serum Response Factor Target Genes.PloS one · 2015Article
- RNase L attenuates mitogen-stimulated gene expression via transcriptional and post-transcriptional mechanisms to limit the proliferative response.The Journal of biological chemistry · 2014Article
- MKL1/2 and ELK4 co-regulate distinct serum response factor (SRF) transcription programs in macrophages.BMC genomics · 2014Article
- Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity.The Journal of biological chemistry · 2014Article
- Transcriptional regulation of flotillins by the extracellularly regulated kinases and retinoid X receptor complexes.PloS one · 2012Article
- Delayed stress fiber formation mediates pulmonary myofibroblast differentiation in response to TGF-β.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- Article
- Critical role of serum response factor in pulmonary myofibroblast differentiation induced by TGF-beta.American journal of respiratory cell and molecular biology · 2009Article
- Comparative promoter region analysis powered by CORG.BMC genomics · 2005Article
- Article
- Cytoskeletal organization in tropomyosin-mediated reversion of ras-transformation: Evidence for Rho kinase pathway.Oncogene · 2001Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Serum Response Factor (SRF) plays a central role in the transcriptional response of mammalian cells to a variety of extracellular signals. It is a key regulator of many cellular early response genes which are believed to be involved in cell growth, differentiation, and development. The mechanism by which SRF activates transcription in response to mitogenic agents has been extensively studied, however, less is known about regulation of the SRF gene itself. Previously, we identified distinct regulatory elements in the SRF promoter that play a role in activation, including an ETS domain binding site, an overlapping Sp1/Egr-1 binding site, and two SRF binding sites. We further showed that serum induces the SRF gene by a mechanism that requires an intact SRF binding site, also termed a CArG box. In the present study we demonstrate that in response to stimulation by cells by lysophosphatidic acid (LPA) or whole serum, the SRF promoter is upregulated by a bipartite pathway that requires both an Sp1 factor binding site and the CArG motifs for maximal stimulation. The CArG box-dependent component of this pathway is targeted by Rho mediated signals, and the Sp1 binding site dependent component is targeted by Ras mediated signals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.