ReviewOncogene1999
Control of development and immunity by rel transcription factors in Drosophila.
Review in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 115 citations in OpenAlex.
- Wound-induced eyespots on butterfly wings at the intersection of immune response and pigmentation development.BMC biology · 2025Article
- Article
- Candidate Regulatory Genes for Hindlimb Development in the Embryos of the Chinese Alligator (Animals : an open access journal from MDPI · 2023Article
- Review
- SUMOylation of Dorsal attenuates Toll/NF-κB signaling.Genetics · 2022Article
- Article
- Temporal specificity and heterogeneity of Drosophila immune cells.The EMBO journal · 2020Article
- Article
- Article
- Article
- Multiple roles of toll-like receptor 4 in colorectal cancer.Frontiers in immunology · 2014Review
- A regulatory pathway, ecdysone-transcription factor relish-cathepsin L, is involved in insect fat body dissociation.PLoS genetics · 2013Article
- Whole transcriptome analysis of a reversible neurodegenerative process in Drosophila reveals potential neuroprotective genes.BMC genomics · 2012Article
- Article
- Asrij maintains the stem cell niche and controls differentiation during Drosophila lymph gland hematopoiesis.PloS one · 2011Article
- Article
- Innate immunity in Drosophila: Pathogens and pathways.Insect science · 2008Article
- Dorsal interacting protein 3 potentiates activation by Drosophila Rel homology domain proteins.Developmental and comparative immunology · 2008Article
- Microarray analyses reveal distinct roles for Rel proteins in the Drosophila immune response.Developmental and comparative immunology · 2008Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Drosophila Rel/NF-kappaB transcription factors - Dorsal, Dif, and Relish - control several biological processes, including embryonic pattern formation, muscle development, immunity, and hematopoiesis. Molecular-genetic analysis of 12 mutations that cause embryonic dorsal/ventral patterning defects has defined the steps that control the formation of this axis. Regulated activation of the Toll receptor leads to the establishment of a gradient of nuclear Dorsal protein, which in turn governs the subdivision of the axis and specification of ventral, lateral and dorsal fates. Phenotypic analysis of dorsal-ventral embryonic mutants and the characterization of the two other fly Rel proteins, Dif and Relish, have shown that the intracellular portion of the Toll to Cactus pathway also controls the innate immune response in Drosophila. Innate immunity and hematopoiesis are regulated by analogous Rel/NF-kappaB-family pathways in mammals. The elucidation of the complex regulation and diverse functions of Drosophila Rel proteins underscores the relevance of basic studies in Drosophila.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.