ArticleBritish journal of pharmacology1999
Leukotrienes are involved in leukocyte recruitment induced by live Histoplasma capsulatum or by the beta-glucan present in their cell wall.
Article in British journal of pharmacology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 62 citations in OpenAlex.
- Article
- Lipid droplets and lipid mediators in viral infection and immunity.FEMS microbiology reviews · 2021Review
- Neutrophil-Mediated Immunopathology and Matrix Metalloproteinases in Central Nervous System - Tuberculosis.Frontiers in immunology · 2021Review
- Article
- CD36 Shunts Eicosanoid Metabolism to Repress CD14 Licensed Interleukin-1β Release and Inflammation.Frontiers in immunology · 2018Article
- Leukotriene BScientific reports · 2017Article
- Hyaluronidase decreases neutrophils infiltration to the inflammatory site.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Article
- Protective Effect of Galectin-1 duringMediators of inflammation · 2016Article
- The leukotriene B₄/BLT₁ axis is a key determinant in susceptibility and resistance to histoplasmosis.PloS one · 2014Article
- The pivotal role of 5-lipoxygenase-derived LTB4 in controlling pulmonary paracoccidioidomycosis.PLoS neglected tropical diseases · 2013Article
- Potential effects of medicinal plants and secondary metabolites on acute lung injury.BioMed research international · 2013Review
- 5-Lipoxygenase deficiency impairs innate and adaptive immune responses during fungal infection.PloS one · 2012Article
- Hyaluronidase recruits mesenchymal-like cells to the lung and ameliorates fibrosis.Fibrogenesis & tissue repair · 2011Article
- Surface architecture of histoplasma capsulatum.Frontiers in microbiology · 2011Article
- Intrapulmonary administration of leukotriene B4 enhances pulmonary host defense against pneumococcal pneumonia.Infection and immunity · 2010Article
- Inhibition of leukotriene biosynthesis abrogates the host control of Mycobacterium tuberculosis.Microbes and infection · 2007Article
- Blockade of endogenous leukotrienes exacerbates pulmonary histoplasmosis.Infection and immunity · 2004Article
- COVID-19: Integrating the Complexity of Systemic and Pulmonary Immunopathology to Identify Biomarkers for Different Outcomes.Frontiers in immunologyReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The inflammatory cell influx towards the peritoneal cavity in mice inoculated i.p. with live or dead Histoplasma capsulatum or with its subcellular preparations was studied. We also evaluated the effects of dexamethasone (Dexa) or MK886, an inhibitor of leukotriene (LT) biosynthesis, on the recruitment of leukocytes. 2. Live yeast form of fungus (LYH) induced an increase in neutrophils (NE) which was highest 4 to 24 h after inoculation. Mononuclear cell (MN) migration beginning at 24 h with a gradual increase over 48 and 168 h, and an eosinophil (EO) recruitment occurs between 24 and 48 h. 3. NE and EO recruitment induced by dead mycelial form of fungus (DMH) was greater than that observed for dead yeast form of fungus (DYH). A similar leukocyte migration pattern was seen after i.p. injection of the alkali-insoluble fraction (F1) from DYH (F1Y) and F1 from DMH (F1M) this being more active than former. The difference in concentration of beta-glucan in DYH and DMH could explain the different inflammatory capacity exhibited by the two forms of H. capsulatum. 4. LT seems to be the principal mediator of leukocyte migration in response to LYH, DYH or DMH or to beta-glucan. However, other mediators appear to contribute to NE and EO migration since the treatment with Dexa was more effective in inhibiting cell migration than MK886. Complement dependent leukocyte migration may participate in this recruitment. Treatment with MK886 completely abolished MN cell migration, indicating its dependence on the presence of LT.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.