ArticleThe Journal of cell biology1999
Cell elongation induces laminin alpha2 chain expression in mouse embryonic mesenchymal cells: role in visceral myogenesis.
Article in The Journal of cell biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 52 citations in OpenAlex.
- Screening Platform for Cell Contact Guidance Based on Inorganic Biomaterial Micro/nanotopographical Gradients.ACS applied materials & interfaces · 2017Article
- Knockdown of Laminin gamma-3 (Lamc3) impairs motoneuron guidance in the zebrafish embryo.Wellcome open research · 2017Article
- Fast-degradable microbeads encapsulating human umbilical cord stem cells in alginate for muscle tissue engineering.Tissue engineering. Part A · 2012Article
- The laminin β1-competing peptide YIGSR induces a hypercontractile, hypoproliferative airway smooth muscle phenotype in an animal model of allergic asthma.Respiratory research · 2010Article
- The extracellular matrix in development and morphogenesis: a dynamic view.Developmental biology · 2010Review
- Embryological origin of airway smooth muscle.Proceedings of the American Thoracic Society · 2008Review
- Laminin-binding integrin alpha7 is required for contractile phenotype expression by human airway myocytes.American journal of respiratory cell and molecular biology · 2007Article
- Synthetic nanostructures inducing differentiation of human mesenchymal stem cells into neuronal lineage.Experimental cell research · 2007Article
- Myogenic Induction of Aligned Mesenchymal Stem Cell Sheets by Culture on Thermally Responsive Electrospun Nanofibers.Advanced materials (Deerfield Beach, Fla.) · 2007Article
- Endogenous laminin is required for human airway smooth muscle cell maturation.Respiratory research · 2006Article
- Clonogenic multipotent stem cells in human adipose tissue differentiate into functional smooth muscle cells.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Lung development in laminin gamma2 deficiency: abnormal tracheal hemidesmosomes with normal branching morphogenesis and epithelial differentiation.Respiratory research · 2006Article
- Article
- Laminin-2 stimulates the proliferation of epithelial cells in a conjunctival epithelial cell line.Cell proliferation · 2004Article
- P311 induces a TGF-beta1-independent, nonfibrogenic myofibroblast phenotype.The Journal of clinical investigation · 2002Article
- High RhoA activity maintains the undifferentiated mesenchymal cell phenotype, whereas RhoA down-regulation by laminin-2 induces smooth muscle myogenesis.The Journal of cell biology · 2002Article
- Stretch-induced alternative splicing of serum response factor promotes bronchial myogenesis and is defective in lung hypoplasia.The Journal of clinical investigation · 2000Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Bronchial smooth muscle (SM) mesenchymal cell precursors change their shape from round to spread/elongated while undergoing differentiation. Here we show that this change in cell shape induces the expression of laminin (LM) alpha2 chain not present in round mesenchymal cells. LM alpha2 expression is reversible and switched on and off by altering the cell's shape in culture. In comparison, the expression of LM beta1 and gamma1 remains unchanged. Functional studies showed that mesenchymal cell spreading and further differentiation into SM are inhibited by an antibody against LM alpha2. Dy/dy mice express very low levels of LM alpha2 and exhibit congenital muscular dystrophy. Lung SM cells isolated from adult dy/dy mice spread defectively and synthesized less SM alpha-actin, desmin, and SM-myosin than controls. These deficiencies were completely corrected by exogenous LM-2. On histological examination, dy/dy mouse airways and gastrointestinal tract had shorter SM cells, and lungs from dy/dy mice contained less SM-specific protein. The intestine, however, showed compensatory hyperplasia, perhaps related to its higher contractile activity. This study therefore demonstrated a novel role for the LM alpha2 chain in SM myogenesis and showed that its decrease in dy/dy mice results in abnormal SM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.